Association Between Triglycerides, High-Density Lipoprotein Cholesterol, and Their Ratio With the Pulse Wave Velocity in Adults From the ELSA-Brasil Study

Universidade Estadual de Montes Claros. Departamento de Fisiopatologia. Montes Claros, MG, Brasil.
Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil.
Universidade de São Paulo. Faculdade de Medicina. INCOR -Instituto do Coração. Clínica Lipídica. São Paulo, SP, Brasil.
Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Divisão de Cardiologia. São Paulo, SP. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Minas Gerais, Faculdade de Medicina. Belo Horizonte, MG, Brasil.
Universidade Federal do Espírito Santo. Programa de Pós-Graduação em Saúde Pública. Vitória, ES, Brasil.
Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Escola de Medicina. Porto Alegre, RS, Brasil.
Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Escola de Medicina. Porto Alegre, RS, Brasil.
Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil.
Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil.
Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil.
Universidade Estadual de Montes Claros. Departamento de Fisiopatologia. Montes Claros, MG, Brasil.

Abstract

Atherogenic dyslipidemia is a risk factor for cardiovascular diseases. The present study aimed to evaluate the association between triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and the triglycerides to high-density lipoprotein (TG/HDL-C) ratio with carotid-femoral pulse wave velocity (cf-PWV), a marker of vascular stiffness. Anthropometric, biochemical, and clinical data from 13,732 adults were used to assess this association. Individuals within the third TG/HDL-C tertile presented worse anthropometric, biochemical, and clinical profiles as compared with the participants in the lower TG/ HDL-C tertile. There was a linear association between TG, HDL-C, and TG/HDL-C ratio and cf-PWV in both men and women (stronger in women). After adjustment for confounders, lower levels of HDL-C were associated with increased cf-PWV in men (9.63 ± .02 m/s) and women (8.90 ± .03 m/s). However, TG was not significantly associated with cf-PWV after adjustment, regardless of sex. An increased TG/HDL-C ratio is associated with higher cf-PWV only in women (9.01 ± .03 m/s), but after adjustment for HDL-C levels, the association was non-significant (8.99 ± .03 m/s). These results highlight the stronger association of HDL-C with arterial stiffness, and that the association of TG/HDL-C with cf-PWV is dependent on HDL-C.

Keywords in Portuguese

Rigidez arterial
Triglicerídeos
Colesterol de lipoproteína de alta densidade
Triglicerídeos/alta densidade
Taxa de colesterol de lipoproteína

Keywords

Arterial stiffness
Triglycerides
High-density lipoprotein cholesterol
Triglycerides/high-density
Lipoprotein cholesterol ratio

Publisher

SAGE

Citation

LELIS, Deborah de Farias et al. Association Between Triglycerides, High-Density Lipoprotein Cholesterol, and Their Ratio With the Pulse Wave Velocity in Adults From the ELSA-Brasil Study. Angiology, v.0(0), p. 1-10, 2022.

DOI

10.1177/00033197221121434

ISSN

1940-1574

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/57425

Type

Copyright

Open access

Embargo date

2028

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