Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5744
Title: Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas.
Authors: Vidal, Maura R. F. S
Barbosa Junior, Aryon de Almeida
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Numerous pulmonary schistosome egg granulomas were present in mice submitted to partial portal vein ligation (Warren's model). The granulomas were characterized by cellular aggregations formed within alveolar tissue. Main cellular types were macrophages (epithelioid cells), eosinophils, plasma cells and lymphocytes. These cells were supported by scanty fibrous stroma and exhibited close membrane contact points amongst themselves, but without forming specialized adhesion apparatus. When granulomas involved arterial structures, proliferation of endothelial and smooth muscle cells occurred and fibrosis associated with angiogenesis became more evident. Granulomas formed around mature eggs in the pulmonary alveolar tissue presented approximately the same size and morphology regardless of the time of infection, the latter being 10, 18 and 25 weeks after cercarial exposure. This persistence of morphological appearance suggests that pulmonary granulomas do not undergo immunological modulation, as is the case with the granulomas in the liver and, to a lesser extent, in the intestines. Probably, besides general immunological factors, local (stromal) factors play an important role in schistosomal granuloma modulation.
Keywords: Experimental schistosomiasis
Pulmonary schistosomiasis
Periovular granuloma
Immunological modulation
DeCS: Granuloma/patologia
Pneumopatias Parasitárias/patologia
Esquistossomose/patologia
Animais
Granuloma/parasitologia
Pulmão/parasitologia
Pulmão/ultraestrutura
Masculino
Camundongos
Óvulo/parasitologia
Veia Porta/cirurgia
Fatores de Tempo
Issue Date: 1993
Citation: VIDAL, M. R. S.; BARBOSA JÚNIOR, A. A.; ANDRADE, Z. A. Experimental pulmonary schistosomiasis: lack of morphological evidence of modulation in schistosomal pulmonary granulomas. Revista do Instituto de Medicina Tropical de São Paulo, v. 35, n. 5, p. 423-9, sep.-oct. 1993.
ISSN: 0036-4665
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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