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| Autor | Gonçalves, Pamela Rosa | |
| Autor | Sousa, Luciana Pereira de | |
| Autor | Gomes, Flávia Lima Ribeiro | |
| Autor | Carvalho, Leonardo José Moura | |
| Autor | Ribeiro, Cláudio Tadeu Daniel | |
| Fecha de acceso | 2023-03-24T12:15:57Z | |
| Fecha de disponibilización | 2023-03-24T12:15:57Z | |
| Fecha de publicación | 2023 | |
| Referencia | GONÇALVES, Pamela Rosa et al. Immunomodulation through vaccination as a promising therapeutic strategy to mitigate malaria-related neurocognitive sequelae. Brain, Behavior, and Immunity, v. 109, p. 102-104, 2023. | en_US |
| ISSN | 0889-1591 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57546 | |
| Idioma | eng | en_US |
| Editor | Elsevier | en_US |
| Derechos de autor | open access | |
| Palabras clave en Portugués | Malária | en_US |
| Palabras clave en Portugués | Disfunção cognitiva | en_US |
| Palabras clave en Portugués | Imunomodulação | en_US |
| Palabras clave en Portugués | Vacina contra tétano-difteria | en_US |
| Palabras clave en Portugués | Melhorador cognitivo | en_US |
| Título | Immunomodulation through vaccination as a promising therapeutic strategy to mitigate malaria-related neurocognitive sequelae | en_US |
| Tipo del documento | Article | |
| Resumen en Inglés | Malaria, an ancient infectious parasitic disease, is caused by protozoa of the genus Plasmodium, whose erythrocytic cycle is accompanied by fever, headache, sweating and chills and a systemic inflammation that can progress to severe forms of disease, including cerebral malaria. Approximately 25% of survivors of this syndrome develop sequelae that may include neurological, neurocognitive, behavioral alterations and poor school performance. Furthermore, some outcomes have also been recorded following episodes of non-severe malaria, which correspond to the most common clinical form of the disease worldwide. There is a body of evidence that neuroinflammation, due to systemic inflammation, plays an important role in the neuropathogenesis of malaria culminating in these cognitive dysfunctions. Preclinical studies suggest that vaccination with type 2 immune response elicitors, such as the tetanus-diphtheria (Td) vaccine, may exert a beneficial immunomodulatory effect by alleviating neuroinflammation. In this viewpoint article, vaccination is proposed as a therapy approach to revert or mitigate neurocognitive deficits associated with malaria. | en_US |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Colégio Pedro II. Campus Duque de Caxias. Laboratório de Biologia. Duque de Caxias, Rio de Janeiro, Brasil. | en_US |
| Afiliación | Colégio Pedro II. Campus Duque de Caxias. Laboratório de Biologia. Duque de Caxias, Rio de Janeiro, Brasil. | en_US |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
| Afiliación | Colégio Pedro II. Campus Duque de Caxias. Laboratório de Biologia. Duque de Caxias, Rio de Janeiro, Brasil. | en_US |
| Palavras clave en Inglês | Malaria | en_US |
| Palavras clave en Inglês | Cognitive dysfunction | en_US |
| Palavras clave en Inglês | Immunomodulation | en_US |
| Palavras clave en Inglês | Tetanus-diphtheria vaccine | en_US |
| Palavras clave en Inglês | Cognitive enhancer | en_US |
| e-ISSN | 10.1016/j.bbi.2023.01.007 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar |
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IOC - Artigos de Periódicos [12978]