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IMMUNOMODULATION THROUGH VACCINATION AS A PROMISING THERAPEUTIC STRATEGY TO MITIGATE MALARIA-RELATED NEUROCOGNITIVE SEQUELAE
Disfunção cognitiva
Imunomodulação
Vacina contra tétano-difteria
Melhorador cognitivo
Cognitive dysfunction
Immunomodulation
Tetanus-diphtheria vaccine
Cognitive enhancer
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Colégio Pedro II. Campus Duque de Caxias. Laboratório de Biologia. Duque de Caxias, Rio de Janeiro, Brasil.
Colégio Pedro II. Campus Duque de Caxias. Laboratório de Biologia. Duque de Caxias, Rio de Janeiro, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
Colégio Pedro II. Campus Duque de Caxias. Laboratório de Biologia. Duque de Caxias, Rio de Janeiro, Brasil.
Colégio Pedro II. Campus Duque de Caxias. Laboratório de Biologia. Duque de Caxias, Rio de Janeiro, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
Colégio Pedro II. Campus Duque de Caxias. Laboratório de Biologia. Duque de Caxias, Rio de Janeiro, Brasil.
Abstract
Malaria, an ancient infectious parasitic disease, is caused by protozoa of the genus Plasmodium, whose erythrocytic
cycle is accompanied by fever, headache, sweating and chills and a systemic inflammation that can
progress to severe forms of disease, including cerebral malaria. Approximately 25% of survivors of this syndrome
develop sequelae that may include neurological, neurocognitive, behavioral alterations and poor school performance.
Furthermore, some outcomes have also been recorded following episodes of non-severe malaria,
which correspond to the most common clinical form of the disease worldwide. There is a body of evidence that
neuroinflammation, due to systemic inflammation, plays an important role in the neuropathogenesis of malaria
culminating in these cognitive dysfunctions. Preclinical studies suggest that vaccination with type 2 immune
response elicitors, such as the tetanus-diphtheria (Td) vaccine, may exert a beneficial immunomodulatory effect
by alleviating neuroinflammation. In this viewpoint article, vaccination is proposed as a therapy approach to
revert or mitigate neurocognitive deficits associated with malaria.
Keywords in Portuguese
MaláriaDisfunção cognitiva
Imunomodulação
Vacina contra tétano-difteria
Melhorador cognitivo
Keywords
MalariaCognitive dysfunction
Immunomodulation
Tetanus-diphtheria vaccine
Cognitive enhancer
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