We propose to understand the biology of vesicular compartmentalized organelle mediated events as “vesicular biology” differentiating between intra and extracellular vesicles. s. Currently, advances in molecular biology, biochemistry, -omics approaches and bioinformatics, enables us to find shared molecular events in morphologically different organelles, vesicles and compartments among wide varieties of eukaryotic pathogens including protozoa and helminth. It will help to understand unique and universal vesicular biology and lead to the development of novel therapeutic strategies.