| Author | Martins, Yuri Chaves | |
| Author | Ribeiro-Gomes, Flávia Lima | |
| Author | Daniel-Ribeiro, Cláudio Tadeu | |
| Access date | 2023-04-15T18:30:43Z | |
| Available date | 2023-04-15T18:30:43Z | |
| Document date | 2023 | |
| Citation | MARTINS, Yuri Chaves; RIBEIRO-GOMES, Flávia Lima; DANIEL-RIBEIRO, Cláudio Tadeu. A short history of innate immunity. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 118, e230023, p. 1-11, 2023. | en_US |
| ISSN | 0074-0206 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57808 | |
| Sponsorship | Financial support: FLR-G and CTD-R are supported by the CNPq, through a Productivity Research Fellowship; CTD-R is a Cientista do Nosso Estado by the FAPERJ. The Laboratório de Pesquisa em Malária (IOC), Fiocruz, is an Associated Laboratory of the INCT em Neuroimunomodulação supported by the CNPq (Project INCT-NIM 465489/2014-1), and of the Rede de Neuroinflamação do Rio de Janeiro financed by FAPERJ (Project Redes/FAPERJ 26010.002418/2019). | |
| Language | eng | en_US |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | en_US |
| Rights | open access | |
| Subject in Portuguese | Resposta imune | en_US |
| Subject in Portuguese | Inflamação | en_US |
| Subject in Portuguese | Imunidade inata | en_US |
| Subject in Portuguese | História | en_US |
| Subject in Portuguese | Imunologia moderna | en_US |
| Title | A short history of innate immunity | en_US |
| Type | Article | |
| DOI | 10.1590/0074-02760230023 | |
| Abstract | Innate immunity refers to the mechanisms responsible for the first line of defense against pathogens, cancer cells and
toxins. The innate immune system is also responsible for the initial activation of the body’s specific immune response (adaptive
immunity). Innate immunity was studied and further developed in parallel with adaptive immunity beginning in the first half
of the 19th century and has been gaining increasing importance to our understanding of health and disease. In the present
overview, we describe the main findings and ideas that contributed to the development of innate immunity as a continually
expanding branch of modern immunology. We start with the toxicological studies by Von Haller and Magendie, in the late
18th and early 19th centuries, and continue with the discoveries in invertebrate immunity that supported the discovery and
characterization of lipopolysaccharide (LPS) and pattern recognition receptors that led to the development of the pattern
recognition and danger theory. | en_US |
| Affilliation | Saint Louis University School of Medicine, Department of Anesthesiology, Saint Louis, MO, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Immune response | en_US |
| Subject | Inflammation | en_US |
| Subject | Innate immunity | en_US |
| Subject | History | en_US |
| Subject | Modern immunology | en_US |
