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A SHORT HISTORY OF INNATE IMMUNITY
Affilliation
Saint Louis University School of Medicine, Department of Anesthesiology, Saint Louis, MO, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
Abstract
Innate immunity refers to the mechanisms responsible for the first line of defense against pathogens, cancer cells and
toxins. The innate immune system is also responsible for the initial activation of the body’s specific immune response (adaptive
immunity). Innate immunity was studied and further developed in parallel with adaptive immunity beginning in the first half
of the 19th century and has been gaining increasing importance to our understanding of health and disease. In the present
overview, we describe the main findings and ideas that contributed to the development of innate immunity as a continually
expanding branch of modern immunology. We start with the toxicological studies by Von Haller and Magendie, in the late
18th and early 19th centuries, and continue with the discoveries in invertebrate immunity that supported the discovery and
characterization of lipopolysaccharide (LPS) and pattern recognition receptors that led to the development of the pattern
recognition and danger theory.
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