Please use this identifier to cite or link to this item:
Type
ArticleCopyright
Open access
Collections
- IOC - Artigos de Periódicos [12821]
Metadata
Show full item record
THE BLESSED UNION OF GLYCOBIOLOGY AND IMMUNOLOGY: A MARRIAGE THAT WORKED
Glicoconjugados
Lectinas
Galectinas
Siglecs
Antígenos oncofetais
Author
Affilliation
Abstract
Abstract: In this article, we discuss the main aspects regarding the recognition of cell surface glycoconjugates
and the immunomodulation of responses against the progression of certain pathologies, such
as cancer and infectious diseases. In the first part, we talk about different aspects of glycoconjugates
and delve deeper into the importance of N-glycans in cancer immunotherapy. Then, we describe two
important lectin families that have been very well studied in the last 20 years. Examples include the
sialic acid-binding immunoglobulin (Ig)-like lectins (siglecs), and galectins. Finally, we discuss a topic
that needs to be better addressed in the field of glycoimmunology: the impact of oncofetal antigens on
the cells of the immune system. New findings in this area are of great importance for advancement,
especially in the field of oncology, since it is already known that cellular interactions mediated by
carbohydrate–carbohydrate and/or carbohydrate proteins are able to modulate the progression of
different types of cancer in events that compromise the functionality of the immune responses.
Keywords in Portuguese
GlicoimunologiaGlicoconjugados
Lectinas
Galectinas
Siglecs
Antígenos oncofetais
Share