Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5816
Title: Dengue hemorrhagic fever is associated with polymorphisms in JAK1
Authors: Silva, Luciano Kalabric
Blanton, Ronald Edward
Parrado, Antonio R
Melo, Paulo S
Morato, Vanessa G
Reis, Eliana Almeida Gomes
Dias, Juarez Pereira
Castro, Jesuina M
Vasconcelos, Pedro F. C
Goddard, Katrina A. B
Barreto, Maurício Lima
Reis, Mitermayer Galvão dos
Teixeira, Glória
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Case University. Center for Global Health and Disease. Cleveland, OH, United State of America
Case University. Division of Genetic Epidemiology, Department of Epidemiology and Biostatistics, Cleveland, OH, United States of America
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Secretaria de Saúde do Estado da Bahia. Diretoria de Vigilância Epidemiológica. Salvador, BA, Brasil
Secretaria de Saúde do Estado da Bahia. Diretoria de Vigilância Epidemiológica. Salvador, BA, Brasil
Instituto Evandro Chagas. Belém, PA, Brasil
Case University. Division of Genetic Epidemiology, Department of Epidemiology and Biostatistics, Cleveland, OH, United States of America
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Abstract: To identify genes associated with the clinical presentation of dengue, 50 cases of probable or possible dengue hemorrhagic fever (DHF), 236 dengue fever (DF), and 236 asymptomatic infections were genotyped for 593 single-nucleotide polymorphisms (SNPs) in 56 genes across the type 1 interferon (IFN) response pathway as well as other important candidate genes. By single locus analysis comparing DHF with DF, 11 of the 51 markers with P<0.05 were in the JAK1 gene. Five markers were significantly associated by false discovery rate criteria (q<0.20 when P<6 × 10(-4)). The JAK1 SNPs showed differential distribution by ethnicity and ancestry consistent with epidemiologic observations in the Americas. The association remained significant after controlling for ancestry and income. No association was observed with markers in the gene encoding CD209 (DC-SIGN). An association between DHF and JAK1 polymorphisms is in agreement with expression profiles showing generalized decreased type 1 IFN-stimulated gene expression in these patients.
Keywords: Flavivirus
Population structure
Interferon
Genetic association
Brazil
DeCS: Febre Hemorágica da Dengue/genética
Predisposição Genética para Doença/genética
Janus Quinase 1/genética
Polimorfismo de Nucleotídeo Único
Adolescente
Adulto
Issue Date: 2010
Citation: SILVA, L. K. et al. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. European Journal of Human Genetics, v. 18, n. 11, p. 12221-1227, nov. 2010.
DOI: 10.1038/ejhg.2010.98
ISSN: 1476-5438
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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