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2030-12-31
Sustainable Development Goals
02 Fome zero e agricultura sustentável
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PERSONALIZED NUTRITION FOR DEPRESSION: IMPACT ON THE UNHOLY TRINITY
Duarte-Silva, Eduardo et al. | Date Issued: 2021
Author
Duarte-Silva, Eduardo
Clarke, Gerard
Dinan, Timothy G.
Peixoto, Christina Alves
Affilliation
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Programa de Pós-Graduação em Biociências e Biotecnologia para a Saúde. Recife, PE, Brasil / Universal Scientific Education and Research Network. Network of Immunity in Infection, Malignancy and Autoimmunity. Recife, PE, Brazil.
University College Cork. Department of Psychiatry and Neurobehavioural Science. Cork, Ireland / 5APC Microbiome Ireland, University College Cork, Cork, Ireland.
University College Cork. Department of Psychiatry and Neurobehavioural Science. Cork, Ireland / 5APC Microbiome Ireland, University College Cork, Cork, Ireland.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia de Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.
Abstract
Major depressive disorder (MDD) is a chronic affective disorder that has a strong neuroinflammatory component underpinning its etiology. Recent studies indicate that MDD is also associated with changes in the gut microbiota and that the latter is mainly modulated by diet. Microbiota-based personalized nutrition aims to provide an individual-specific diet that will yield the maximum benefit from a given diet since the gut microbiota is accounted for the variations that individuals present in response to a given food. In this review, we present and discuss 5 possible outcomes of using microbiota-based personalized nutrition. Harnessing this approach is essential to design more accurate therapies to prevent and treat MDD or to even help in drug metabolism, especially in the case of antidepressants.
Keywords
Neuroinflammation
Major depressive disorder
Gut microbiota
Personalized nutrition
 
Publisher
S. Karger Medical and Scientific Publishers
Citation
DUARTE-SILVA, Eduardo et al. Personalized Nutrition for Depression: impact on the unholy trinity. Neuroimmunomodulation, v. 28, n. 2, p. 47-51, Mar. 2021.
DOI
10.1159/000514094
ISSN
1423-0216