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2099-12-31
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LOW-DOSE OF BENZNIDAZOLE PROMOTES THERAPEUTIC CURE IN EXPERIMENTAL CHRONIC CHAGAS' DISEASE WITH ABSENCE OF PARASITISM IN BLOOD, HEART AND COLON
Perin, Luísa et al. | Date Issued: 2020
Author
Perin, Luísa
Fonseca, Kátia da Silva
Carvalho, Thaís Vieira de
Carvalho, Lívia Mendes
Madeira, João Vitor
Medeiros, Luciana da Fonseca
Molina, Israel
Oliveira, Rodrigo Correa
Carneiro, Cláudia Martins
Vieira, Paula Melo de Abreu
Affilliation
Laboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil.
Laboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil.
Laboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil/Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazil.
Laboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil/Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazil.
Laboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil.
Laboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil.
Laboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil/Tropical Medicine and International Health Unit. Department of Infectious Diseases. Vall d'Hebron University Hospital. Universitat Autònoma de Barcelona. PROSICS Barcelona. Barcelona, Spain.
Laboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil/Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Laboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil/Department of Clinical Analysis. School of Pharmacy. Federal University of Ouro Preto. Ouro Preto, MG, Brazil.
Laboratory of Immunopathology. Nucleus of Biological Sciences Research. Federal University of Ouro Preto. Ouro Preto, MG, Brazil/Laboratory of Morphopathology. Department of Biological Sciences. Nucleus of Biological Sciences Research. Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazil.
Abstract
Studies suggest that the dose of the standard benznidazole (BNZ) treatment regimen might be too high. We investigated the efficacy of BNZ 20 and 40 mg/kg/day compared with standard dose (100 mg/kg/day) to induce cure in mice infected with Trypanosome cruzi Y strain in the acute and chronic phases of Chagas' disease. Our findings indicate that an experimental treatment with a BNZ low-dose (40 mg/kg/day) is similarly effective as the usual dose in the chronic mice model (100% of cure). In addition, the treatment in the chronic model of Chagas' disease presented better results than the acute model and colon appears to be a key tissue when it comes to evaluating treatment efficacy compared to blood and heart. Therefore, our data suggest the reconsideration of the current therapy, mainly in the chronic phase of the disease.
Keywords
Chagas disease
Trypanosoma cruzi
Benznidazole
Low-dose
Treatment
 
Publisher
Academic Press
Citation
PERIN, Luísa et al. Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon. Exp Parasitol., v. 210, 107834, 2020. doi: 10.1016/j.exppara.2020.107834.
DOI
10.1016/j.exppara.2020.107834
ISSN
0014-4894