| Author | Siveira, Alexandre Barcelos Morais da | |
| Author | Araújo, Fernanda Fortes de | |
| Author | Freitas, Michelle A. Ribeiro | |
| Author | Gomes, Juliana Assis Silva | |
| Author | Chaves, Ana Thereza | |
| Author | Oliveira, Enio C. de | |
| Author | G. Neto, Salustiano | |
| Author | Luquetti, Alejandro O. | |
| Author | Souza, Gilmar da Cunha | |
| Author | Bernardino Júnior, Roberto | |
| Author | Fujiwara, Ricardo | |
| Author | Reis, Dêbora d’A´ vila | |
| Author | Oliveira, Rodrigo Correa | |
| Access date | 2023-05-22T18:28:18Z | |
| Available date | 2023-05-22T18:28:18Z | |
| Document date | 2009 | |
| Citation | SILVEIRA, Alexandre B M da et al. Characterization of the presence and distribution of Foxp3(+) cells in chagasic patients with and without megacolon. Hum Immunol., v. 70, n. 1, p. 65-67, 2009. doi: 10.1016/j.humimm.2008.10.015. | en_US |
| ISSN | 0198-8859 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/58560 | |
| Sponsorship | FUNDAÇÃO OSWALDO CRUZ | en_US |
| Language | eng | en_US |
| Rights | restricted access | |
| Title | Characterization of the presence and distribution of Foxp3(+) cells in chagasic patients with and without megacolon | en_US |
| Type | Article | |
| DOI | 10.1016/j.humimm.2008.10.015 | |
| Abstract | Patients with Chagas's disease in the chronic phase regularly present with the chagasic megacolon. This form is characterized by inflammation, neuronal destruction, and organ dilatation. Chagasic patients with megacolon always present with inflammatory process near the enteric plexuses of the colon, as previously demonstrated. The aim of this study is to characterize the presence and distribution of Foxp3(+) cells in the muscle layers and neuronal plexuses area of the colon from chagasic patients with and without megacolon. Our results demonstrated that chagasic patients without megacolon presented with an increased concentration of Foxp3(+) cells in all colon layers compared with chagasic patients with megacolon and noninfected individuals. These cells were situated mainly near the blood vessels and rarely were associated with the inflammatory foci. We believe that the presence of Foxp3(+) cells may help to control the inflammatory process through the management of lymphocyte migration and, consequently, prevent neuronal destruction and chagasic megacolon development. (c) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved | en_US |
| Affilliation | Human Anatomy Sector, Biomedical Institut Sciences. Universidade Federal de Uberlândia. Uberlândia, MG, Brazil | en_US |
| Affilliation | Research Center Renè Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Parasitology Sector. Biomedical Institut Sciences. Universidade Federal de Uberlándia. Uberlándia, MG, Brazil | en_US |
| Affilliation | Research Center Renè Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Research Center Renè Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Department of Surgery. Medical School. Universidade Federal de Goiàs. Goiania, GO, Brazil | en_US |
| Affilliation | Department of Surgery. Medical School. Universidade Federal de Goiàs. Goiania, GO, Brazil | en_US |
| Affilliation | Department of Surgery. Medical School. Universidade Federal de Goiàs. Goiania, GO, Brazil | en_US |
| Affilliation | Human Anatomy Sector, Biomedical Institut Sciences. Universidade Federal de Uberlândia. Uberlândia, MG, Brazil | en_US |
| Affilliation | Human Anatomy Sector, Biomedical Institut Sciences. Universidade Federal de Uberlândia. Uberlândia, MG, Brazil | en_US |
| Affilliation | Research Center Renè Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Department of Morphology. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Research Center Renè Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil | en_US |
| Subject | Chagas's disease | en_US |
| Subject | Chagasic megacolon | en_US |
| Subject | Inflammatory process | en_US |
| Subject | Foxp3 cells | en_US |
| Embargo date | 2099-12-31 | |
