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CHARACTERIZATION OF THE PRESENCE AND DISTRIBUTION OF FOXP3(+) CELLS IN CHAGASIC PATIENTS WITH AND WITHOUT MEGACOLON
Siveira, Alexandre Barcelos Morais da et al. | Date Issued: 2009
Author
Siveira, Alexandre Barcelos Morais da
Araújo, Fernanda Fortes de
Freitas, Michelle A. Ribeiro
Gomes, Juliana Assis Silva
Chaves, Ana Thereza
Oliveira, Enio C. de
G. Neto, Salustiano
Luquetti, Alejandro O.
Souza, Gilmar da Cunha
Bernardino Júnior, Roberto
Fujiwara, Ricardo
Reis, Dêbora d’A´ vila
Oliveira, Rodrigo Correa
Affilliation
Human Anatomy Sector, Biomedical Institut Sciences. Universidade Federal de Uberlândia. Uberlândia, MG, Brazil
Research Center Renè Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil
Parasitology Sector. Biomedical Institut Sciences. Universidade Federal de Uberlándia. Uberlándia, MG, Brazil
Research Center Renè Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil
Research Center Renè Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil
Department of Surgery. Medical School. Universidade Federal de Goiàs. Goiania, GO, Brazil
Department of Surgery. Medical School. Universidade Federal de Goiàs. Goiania, GO, Brazil
Department of Surgery. Medical School. Universidade Federal de Goiàs. Goiania, GO, Brazil
Human Anatomy Sector, Biomedical Institut Sciences. Universidade Federal de Uberlândia. Uberlândia, MG, Brazil
Human Anatomy Sector, Biomedical Institut Sciences. Universidade Federal de Uberlândia. Uberlândia, MG, Brazil
Research Center Renè Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil
Department of Morphology. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Research Center Renè Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil
Abstract
Patients with Chagas's disease in the chronic phase regularly present with the chagasic megacolon. This form is characterized by inflammation, neuronal destruction, and organ dilatation. Chagasic patients with megacolon always present with inflammatory process near the enteric plexuses of the colon, as previously demonstrated. The aim of this study is to characterize the presence and distribution of Foxp3(+) cells in the muscle layers and neuronal plexuses area of the colon from chagasic patients with and without megacolon. Our results demonstrated that chagasic patients without megacolon presented with an increased concentration of Foxp3(+) cells in all colon layers compared with chagasic patients with megacolon and noninfected individuals. These cells were situated mainly near the blood vessels and rarely were associated with the inflammatory foci. We believe that the presence of Foxp3(+) cells may help to control the inflammatory process through the management of lymphocyte migration and, consequently, prevent neuronal destruction and chagasic megacolon development. (c) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved
Keywords
Chagas's disease
Chagasic megacolon
Inflammatory process
Foxp3 cells
 
Citation
SILVEIRA, Alexandre B M da et al. Characterization of the presence and distribution of Foxp3(+) cells in chagasic patients with and without megacolon. Hum Immunol., v. 70, n. 1, p. 65-67, 2009. doi: 10.1016/j.humimm.2008.10.015.
DOI
10.1016/j.humimm.2008.10.015
ISSN
0198-8859