Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5858
Title: First insights into the genetic diversity of Mycobacterium tuberculosis strains in Salvador, Bahia State, Brazil.
Authors: Silva, Aída Cristina do Nascimento
Ferrazoli, Lucilaine
Simonsen, Vera
Reis, Joice Neves
Pereira, Susan Martins
Carmo, Theomira Mauadie de Azevedo
Mota, Eduardo Luiz Andrade
Reis, Mitermayer Galvão dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil
Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: This study constitutes a first attempt to describe the genetic population structure of Mycobacterium tuberculosis circulating in Salvador, Bahia State, Brazil. A total of 56 confirmed cases of pulmonary tuberculosis, identified between March and June 2008, were analyzed using restriction fragment length polymorphism (IS6110-RFLP). The study population was characterized by a predominance of males (71.43%) over 30 years of age (68.75%). Forty-one isolates were found to belong to a single pattern (73.2%), while 15 (26.7%) were found in group patterns, forming six clusters. The higher level of diversity observed is much more suggestive of endogenous reactivation than recent transmission.
Keywords: Molecular Epidemiology
Genetic variation
Mycobacterium tuberculosis
DeCS: Variação Genética
Mycobacterium tuberculosis/genética
Tuberculose Pulmonar/microbiologia
Adulto
Distribuição por Idade
Brasil
Feminino
Humanos
Masculino
Polimorfismo de Fragmento de Restrição
Distribuição por Sexo
Tuberculose Pulmonar/genética
Adulto Jovem
Issue Date: 2011
Citation: SILVA, A.C. et al. First insights into the genetic diversity of Mycobacterium tuberculosis strains in Salvador, Bahia State, Brazil. Cadernos de Saúde Pública, v. 27, n. 9, p. 1859-63, sep. 2011.
ISSN: 1678-4464
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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