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AGE-SPECIFIC PREVALENCE OF ANAL AND CERVICAL HUMAN PAPILLOMAVIRUS INFECTION AND HIGH-GRADE LESIONS IN 11 177 WOMEN BY HUMAN IMMUNODEFICIENCY VIRUS STATUS: A COLLABORATIVE POOLED ANALYSIS OF 26 STUDIES
Author
Feixue, Wei
Ningshao, Xia
Ocampo, Rebeca
Goodman, Marc T.
Hessol, Nancy A.
Grinsztejn, Beatriz
Ortiz, Ana P.
Fanghui, Zhao
Kojic, Erna M.
Kaul, Rupert
Heard, Isabelle
Morhason-Bello, Imran O.
Moscicki, Anna-Barbara
Pokomandy, Alexandra de
Palefsky, Joel M.
Rodrigues, Luana L. S.
Mandishora, Racheal S. Dube
Ramautarsing, Reshmie A.
Franceschi, Silvia
Godbole, Sheela V.
Tso, Fernanda K.
Menezes, Lynette J.
Chunqing, Lin
Clifford, Gary M.
Ningshao, Xia
Ocampo, Rebeca
Goodman, Marc T.
Hessol, Nancy A.
Grinsztejn, Beatriz
Ortiz, Ana P.
Fanghui, Zhao
Kojic, Erna M.
Kaul, Rupert
Heard, Isabelle
Morhason-Bello, Imran O.
Moscicki, Anna-Barbara
Pokomandy, Alexandra de
Palefsky, Joel M.
Rodrigues, Luana L. S.
Mandishora, Racheal S. Dube
Ramautarsing, Reshmie A.
Franceschi, Silvia
Godbole, Sheela V.
Tso, Fernanda K.
Menezes, Lynette J.
Chunqing, Lin
Clifford, Gary M.
Affilliation
Early Detection, Prevention and Infections Branch. International Agency for Research on Cancer/World Health Organization. Lyon, France.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics. National Institute of Diagnostics and Vaccine Development in Infectious Diseases. School of Public Health. Xiamen University. Xiamen, Fujian, China.
Agencia Costarricense de Investigaciones Biomédicas-Fundación INCIENSA. San José, Costa Rica.
Cancer Prevention and Control Program. Samuel Oschin Comprehensive Cancer Institute. Cedars-Sinai Medical Center. Los Angeles, California, USA.
University of California. Department of Clinical Pharmacy. San Francisco, California, USA / University of California. Department of Medicine. San Francisco, California, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.
Puerto Rico Cancer Control and Population Sciences Division. University of Puerto Rico Comprehensive Cancer Center. San Juan, Puerto Rico / Department of Biostatistics and Epidemiology. Graduate School of Public Health. Medical Sciences Campus. University of Puerto Rico. San Juan, Puerto Rico.
Department of Cancer Epidemiology. National Cancer Center & Cancer Hospital. Chinese Academy of Medical Sciences. Beijing, China.
Division of Infectious Diseases. Department of Medicine. Mount Sinai West and Morningside. New York, NY, USA.
Department of Medicine. University of Toronto and University Health Network. Toronto, Ontario, Canada.
Department of Endocrinology and Reproductive Medicine. Institut Endocrinologie, Maladies Métaboliques et Médecine Interne, Assistance Publique - Hôpitaux de Paris. Groupe Hospitalier Pitié- Salpêtrière. Paris, France.
Department of Obstetrics and Gynaecology. College of Medicine. University of Ibadan. Ibadan, Oyo State, Nigeria / Institute of Advanced Medical Research and Training. College of Medicine. University of Ibadan. Ibadan, Oyo State, Nigeria.
Department of Pediatrics. University of California. Los Angeles, California, USA.
McGill University Department of Family Medicine and McGill University Health Centre. Montreal, Quebec, Canada.
University of California. Department of Medicin. San Francisco, California, USA.
Universidade Federal do Oeste do Pará. Instituto de Saúde Coletiva. Programa de Pós-Graduação em Ciências da Saúde. Santarém, PA, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brazil.
Early Detection, Prevention and Infections Branch. International Agency for Research on Cancer/World Health Organization. Lyon, France / Medical Microbiology Unit. University of Zimbabwe. Faculty of Health Sciences. Harare, Zimbabwe.
Institute of HIV Research and Innovation. Bangkok, Thailand.
Centro di Riferimento Oncologico. Istituto di Ricovero e Cura a Carattere Scientifico. Aviano, Italy.
Division of Epidemiology and Biostatistics. Indian Council of Medical Research, National AIDS Research Institute. Pune, India.
Federal University of São Paulo. Department of Gynecology. São Paulo, SP, Brazil.
Division of Infectious Disease and International Medicine. University of South Florida. Tampa, Florida, USA.
National Cancer Center. National Clinical Research Center for Cancer. Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing, China.
Early Detection, Prevention and Infections Branch. International Agency for Research on Cancer/World Health Organization. Lyon, France.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics. National Institute of Diagnostics and Vaccine Development in Infectious Diseases. School of Public Health. Xiamen University. Xiamen, Fujian, China.
Agencia Costarricense de Investigaciones Biomédicas-Fundación INCIENSA. San José, Costa Rica.
Cancer Prevention and Control Program. Samuel Oschin Comprehensive Cancer Institute. Cedars-Sinai Medical Center. Los Angeles, California, USA.
University of California. Department of Clinical Pharmacy. San Francisco, California, USA / University of California. Department of Medicine. San Francisco, California, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.
Puerto Rico Cancer Control and Population Sciences Division. University of Puerto Rico Comprehensive Cancer Center. San Juan, Puerto Rico / Department of Biostatistics and Epidemiology. Graduate School of Public Health. Medical Sciences Campus. University of Puerto Rico. San Juan, Puerto Rico.
Department of Cancer Epidemiology. National Cancer Center & Cancer Hospital. Chinese Academy of Medical Sciences. Beijing, China.
Division of Infectious Diseases. Department of Medicine. Mount Sinai West and Morningside. New York, NY, USA.
Department of Medicine. University of Toronto and University Health Network. Toronto, Ontario, Canada.
Department of Endocrinology and Reproductive Medicine. Institut Endocrinologie, Maladies Métaboliques et Médecine Interne, Assistance Publique - Hôpitaux de Paris. Groupe Hospitalier Pitié- Salpêtrière. Paris, France.
Department of Obstetrics and Gynaecology. College of Medicine. University of Ibadan. Ibadan, Oyo State, Nigeria / Institute of Advanced Medical Research and Training. College of Medicine. University of Ibadan. Ibadan, Oyo State, Nigeria.
Department of Pediatrics. University of California. Los Angeles, California, USA.
McGill University Department of Family Medicine and McGill University Health Centre. Montreal, Quebec, Canada.
University of California. Department of Medicin. San Francisco, California, USA.
Universidade Federal do Oeste do Pará. Instituto de Saúde Coletiva. Programa de Pós-Graduação em Ciências da Saúde. Santarém, PA, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brazil.
Early Detection, Prevention and Infections Branch. International Agency for Research on Cancer/World Health Organization. Lyon, France / Medical Microbiology Unit. University of Zimbabwe. Faculty of Health Sciences. Harare, Zimbabwe.
Institute of HIV Research and Innovation. Bangkok, Thailand.
Centro di Riferimento Oncologico. Istituto di Ricovero e Cura a Carattere Scientifico. Aviano, Italy.
Division of Epidemiology and Biostatistics. Indian Council of Medical Research, National AIDS Research Institute. Pune, India.
Federal University of São Paulo. Department of Gynecology. São Paulo, SP, Brazil.
Division of Infectious Disease and International Medicine. University of South Florida. Tampa, Florida, USA.
National Cancer Center. National Clinical Research Center for Cancer. Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing, China.
Early Detection, Prevention and Infections Branch. International Agency for Research on Cancer/World Health Organization. Lyon, France.
Abstract
Background: Age-specific data on anal, and corresponding cervical, human papillomavirus (HPV) infection are needed to inform female anal cancer prevention. Methods: We centrally reanalyzed individual-level data from 26 studies reporting HPV prevalence in paired anal and cervical samples by human immunodeficiency virus (HIV) status and age. For women with HIV (WWH) with anal high-grade squamous intraepithelial lesions or worse (HSIL+), we also investigated concurrent cervical cytopathology. Results: In HIV-negative women, HPV16 prevalence decreased significantly with age, both at anus (4.3% at 15-24 years to 1.0% at ≥55 years; ptrend = 0.0026) and cervix (7.4% to 1.7%; ptrend < 0.0001). In WWH, HPV16 prevalence decreased with age at cervix (18.3% to 7.2%; ptrend = 0.0035) but not anus (11.5% to 13.9%; ptrend = 0.5412). Given anal HPV16 positivity, concurrent cervical HPV16 positivity also decreased with age, both in HIV-negative women (ptrend = 0.0005) and WWH (ptrend = 0.0166). Among 48 WWH with HPV16-positive anal HSIL+, 27 (56%) were cervical high-risk HPV-positive, including 8 with cervical HPV16, and 5 were cervical HSIL+. Conclusions: Age-specific shifts in HPV16 prevalence from cervix to anus suggest that HPV infections in the anus persist longer, or occur later in life, than in the cervix, particularly in WWH. This is an important consideration when assessing the utility of cervical screening results to stratify anal cancer risk.
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