Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5863
Title: Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
Authors: Andrade, Bruno de Bezerril
Santos, Cristiane J. N
Camargo, Luis M
Souza Neto, Sebastião Martins
Reis Filho, Antonio José Souza
Clarêncio, Jorge
Mendonça, Vitor Rosa Ramos de
Luz, Nívea Farias
Camargo, Erney P
Barral, Aldina Maria Prado
Silva, Antonio Augusto Moura da
Barral Netto, Manoel
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal do Maranhão. Centro de Ciências da Saúde. São Luis, MA, Brasil
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Areas that are endemic for malaria are also highly endemic for hepatitis B virus (HBV) infection. Nevertheless, it is unknown whether HBV infection modifies the clinical presentation of malaria. This study aimed to address this question. METHODOLOGY AND FINDINGS: An observational study of 636 individuals was performed in Rondônia, western Amazon, Brazil between 2006 and 2007. Active and passive case detections identified Plasmodium infection by field microscopy and nested Polymerase Chain Reaction (PCR). HBV infections were identified by serology and confirmed by real-time PCR. Epidemiological information and plasma cytokine profiles were studied. The data were analyzed using adjusted multinomial logistic regression. Plasmodium-infected individuals with active HBV infection were more likely to be asymptomatic (OR: 120.13, P<0.0001), present with lower levels of parasitemia and demonstrate a decreased inflammatory cytokine profile. Nevertheless, co-infected individuals presented higher HBV viremia. Plasmodium parasitemia inversely correlated with plasma HBV DNA levels (r = -0.6; P = 0.0003). CONCLUSION: HBV infection diminishes the intensity of malaria infection in individuals from this endemic area. This effect seems related to cytokine balance and control of inflammatory responses. These findings add important insights to the understanding of the factors affecting the clinical outcomes of malaria in endemic regions.
DeCS: Hepatite B/epidemiologia
Hepatite B/etiologia
Malária/complicações
Plasmodium falciparum/patogenicidade
Plasmodium vivax/patogenicidade
Adolescente
Adulto
Brasil/epidemiologia
Criança
Pré-Escolar
Citocinas/metabolismo
DNA Viral/genética
Feminino
Hepatite B/diagnóstico
Anticorpos Anti-Hepatite B
Antígenos de Superfície da Hepatite B
Vírus da Hepatite B/genética
Humanos
Malária/virologia
Masculino
Meia-Idade
Fatores de Risco
Adulto Jovem
Issue Date: 2011
Citation: ANDRADE, B.B. et al. Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon. PLoS One, v. 6, n. 5, p. e19841, 2011.
DOI: 10.1371/journal.pone.0019841
ISSN: 1932-6203
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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