Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5870
Title: Distinct patterns of microvasculature in the cutaneous lesions of leprosy
Authors: Antunes, Sergio Luiz Gomes
Mota, Ester Maria
Almeida, Sonia Maria Rocha de
Gallo, Maria Eugenia
Nery, Jose Augusto da Costa
Lenzi, Henrique Leonel
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil/ Universidade de Nova Iguaçu. Nova Iguaçu, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil
Abstract: This work is an investigation on the microvasculature of the cutaneous infiltrates of leprosy with the immunohistochemical staining of endothelial cells in cutaneous biopsies. Anti-Factor VIII-related antigen antibody (anti-FVIII-ra) and Ulex Europaeus-1 lectin (UEA-1) binding were utilized as endothelial cell markers. Thirty-nine patients grouped according to the Ridley-Jopling classification (14 borderline tuberculoid, 18 borderline lepromatous, 6 lepromatous, and 1 indeterminate leprosy) were selected for this study. Two microvascular architectural patterns could be clearly distinguished: lepromatous lesions presented a dense and tortuous mesh of microvessels among the Mycobacterium leprae-glutted macrophages; whereas the microvessels in the tuberculoid lesions were restricted to the periphery of the granulomas and were not seen among the central epithelioid cells. We were able to distinguish three basic morphological kinds of infiltrate distribution related to the microvessels: micronodules, cords and macronodules. Intensifications of the FVIII-ra immunoreactivity and UEA-1 binding capacity were observed in the endothelial cells of microvessels involved by the inflammatory infiltrate. A distinct cytokine expression profile at the leprosy poles and the role of mast cells in angiogenesis were speculated as factors contributing to these distinct patterns. Growth of the lesion and systemic dissemination of M. leprae in the bipolar spectrum of leprosy may hypothetically be influenced by the vascular-infiltrate relationship. The detection of angiogenesis in the cutaneous lesions of leprosy may bring about alternate and/or additional strategies for leprosy treatment.
Keywords: cutaneous lesions
leprosy
anti-FVIII-ra
Europaeus-1 lectin
Mycobacterium leprae
immunohistochemical
DeCS: Biópsia
Endotélio
Granuloma
Imunoistoquímica
Hanseníase Virchowiana
Hanseníase Tuberculóide
Fator de von Willebrand
Pele, irrigação sanguínea
Issue Date: 2000
Citation: ANTUNES, S. L. G. Et al. Distinct patterns of microvasculature in the cutaneous lesion of leprosy. International Journal of Leprosy and other Mycobacterial Diseases, v. 68, n.2, p. 143-151, 2000.
ISSN: 1148-916X
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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