| Author | Silva, Maria Betânia Souza da | |
| Author | Andrade, Tarcisio Mattos de | |
| Author | Silva, Luciano Kalabric | |
| Author | Rodart, Itatiana Ferreira | |
| Author | Lopes, Gisele Barreto | |
| Author | Carmo, Theomira Mauadie de Azevedo | |
| Author | Zarife, Maria Alice Sant’Anna | |
| Author | Dourado, Inês | |
| Author | Reis, Mitermayer Galvão dos | |
| Access date | 2012-12-06T18:04:23Z | |
| Available date | 2012-12-06T18:04:23Z | |
| Document date | 2010 | |
| Citation | SILVA, M. B. S. et al. Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil. Memórias do Instituto Oswaldo Cruz, v. 105, n. 3, p. 299-303, may.2010. | pt_BR |
| ISSN | 1678-8060 | |
| URI | https://www.arca.fiocruz.br/handle/icict/5931 | |
| Language | eng | pt_BR |
| Rights | open access | |
| Title | Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil | pt_BR |
| Type | Article | pt_BR |
| Abstract | Hepatitis C virus (HCV) is the major infectious disease agent among injecting drug users (IDUs), with seroprevalence ranging from 50-90 percent. In this paper, serological and virological parameters were investigated among 194 IDUs, 94 ex-IDUs and 95 non-IDUs that were sampled by the "snowball" technique in three localities renowned for both intense drug use and trafficking activities in Salvador, Brazil. The majority of the participants were male, but sex and mean age differed significantly between IDUs/ex-IDUs and non-IDUs (p < 0.05). Anti-HCV screening revealed that 35.6 percent, 29.8 percent and 5.3 percent of samples from IDUs, ex-IDUs and non-IDUs, respectively, were seropositive. HCV-RNA detection confirmed that the prevalence of infection was 29.4 percent, 21.3 percent and 5.3 percent for IDUs, ex-IDUs and non-IDUs, respectively. Genotyping analysis among IDUs/ex-IDUs determined that 76.9 percent were infected with genotype 1, 18.5 percent with genotype 3 and 4.6 percent with a mixed genotype; this result differed significantly from non-IDUs, where genotype 3 was the most frequent (60 percent), followed by genotype 1 (20 percent) and a mixed genotype (20 percent). We report a significantly higher prevalence of HCV infection in IDUs/ex-IDUs compared to the control group (p < 0.001). Although the sample size of our study was small, the differences in HCV genotype distribution reported herein for IDUs/ex-IDUs and non-IDUs warrant further investigation. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Aliança de Redução de Danos Fátima Cavalcanti. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Laboratório Central da Bahia. Departamento de Saúde da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Subject | HCV | pt_BR |
| Subject | Injecting drug users | pt_BR |
| Subject | HCV genotypes | pt_BR |
| Subject | Prevalence | pt_BR |
| Subject | Brazil | pt_BR |
| DeCS | Hepacivirus/genética | pt_BR |
| DeCS | Hepatite C/epidemiologia | pt_BR |
| DeCS | Anticorpos Anti-Hepatite C/sangue | pt_BR |
| DeCS | RNA Viral/sangue | pt_BR |
| DeCS | Abuso de Substâncias por Via Intravenosa/epidemiologia | pt_BR |
| DeCS | Brasil/epidemiologia | pt_BR |
| DeCS | Estudos de Casos e Controles | pt_BR |
| DeCS | Genótipo | pt_BR |
| DeCS | Hepacivirus/imunologia | pt_BR |
| DeCS | Hepatite C/virologia | pt_BR |
| DeCS | Prevalência | pt_BR |
| DeCS | RNA Viral/genética | pt_BR |
| DeCS | Estudos Soroepidemiológicos | pt_BR |
| DeCS | Abuso de Substâncias por Via Intravenosa/complicações | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Masculino | pt_BR |
