Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5931
Title: Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil
Authors: Silva, Maria Betânia Souza da
Andrade, Tarcisio Mattos de
Silva, Luciano Kalabric
Rodart, Itatiana Ferreira
Lopes, Gisele Barreto
Carmo, Theomira Mauadie de Azevedo
Zarife, Maria Alice Sant’Anna
Dourado, Inês
Reis, Mitermayer Galvão dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Aliança de Redução de Danos Fátima Cavalcanti. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Laboratório Central da Bahia. Departamento de Saúde da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Pública. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Hepatitis C virus (HCV) is the major infectious disease agent among injecting drug users (IDUs), with seroprevalence ranging from 50-90 percent. In this paper, serological and virological parameters were investigated among 194 IDUs, 94 ex-IDUs and 95 non-IDUs that were sampled by the "snowball" technique in three localities renowned for both intense drug use and trafficking activities in Salvador, Brazil. The majority of the participants were male, but sex and mean age differed significantly between IDUs/ex-IDUs and non-IDUs (p < 0.05). Anti-HCV screening revealed that 35.6 percent, 29.8 percent and 5.3 percent of samples from IDUs, ex-IDUs and non-IDUs, respectively, were seropositive. HCV-RNA detection confirmed that the prevalence of infection was 29.4 percent, 21.3 percent and 5.3 percent for IDUs, ex-IDUs and non-IDUs, respectively. Genotyping analysis among IDUs/ex-IDUs determined that 76.9 percent were infected with genotype 1, 18.5 percent with genotype 3 and 4.6 percent with a mixed genotype; this result differed significantly from non-IDUs, where genotype 3 was the most frequent (60 percent), followed by genotype 1 (20 percent) and a mixed genotype (20 percent). We report a significantly higher prevalence of HCV infection in IDUs/ex-IDUs compared to the control group (p < 0.001). Although the sample size of our study was small, the differences in HCV genotype distribution reported herein for IDUs/ex-IDUs and non-IDUs warrant further investigation.
Keywords: HCV
Injecting drug users
HCV genotypes
Prevalence
Brazil
DeCS: Hepacivirus/genética
Hepatite C/epidemiologia
Anticorpos Anti-Hepatite C/sangue
RNA Viral/sangue
Abuso de Substâncias por Via Intravenosa/epidemiologia
Brasil/epidemiologia
Estudos de Casos e Controles
Genótipo
Hepacivirus/imunologia
Hepatite C/virologia
Prevalência
RNA Viral/genética
Estudos Soroepidemiológicos
Abuso de Substâncias por Via Intravenosa/complicações
Adulto
Feminino
Humanos
Masculino
Issue Date: 2010
Citation: SILVA, M. B. S. et al. Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil. Memórias do Instituto Oswaldo Cruz, v. 105, n. 3, p. 299-303, may.2010.
ISSN: 1678-8060
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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