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| Autor | Cleare, Levi G. | |
| Autor | Zamith, Daniel | |
| Autor | Heyman, Heino M. | |
| Autor | Couvillion, Sneha P. | |
| Autor | Nimrichter, Leonardo | |
| Autor | Rodrigues, Marcio L. | |
| Autor | Nakayasu, Ernesto S. | |
| Autor | Nosanchuk, Joshua D. | |
| Fecha de acceso | 2023-07-03T21:00:25Z | |
| Fecha de disponibilización | 2023-07-03T21:00:25Z | |
| Fecha de publicación | 2020 | |
| Referencia | CLEARE, Levi G. et al. Media matters! Alterations in the loading and release of Histoplasma capsulatum extracellular vesicles in response to different nutritional milieus. Cellular Microbiology, v. 22, n. 9, p. 1-32, 2020. | |
| ISSN | 1462-5814 | |
| URI | https://www.arca.fiocruz.br/handle/icict/59380 | |
| Idioma | eng | en_US |
| Editor | Wiley-Blackwell | |
| Documento relacionado | https://www.arca.fiocruz.br/handle/icict/59387 | |
| Derechos de autor | open access | |
| MeSH | Culture Media | en_US |
| MeSH | Extracellular Vesicles | en_US |
| MeSH | Fungal Proteins | en_US |
| MeSH | Histoplasma | en_US |
| MeSH | Nutrients | en_US |
| Título | Media matters! Alterations in the loading and release of Histoplasma capsulatum extracellular vesicles in response to different nutritional milieus | en_US |
| Tipo del documento | Preprint | |
| DOI | 10.1111/CMI.13217 | |
| Resumen en Inglés | Histoplasma capsulatum is a dimorphic fungus that most frequently causes pneumonia, but can also disseminate and proliferate in diverse tissues. Histoplasma capsulatum has a complex secretion system that mediates the release of macromolecule-degrading enzymes and virulence factors. The formation and release of extracellular vesicles (EVs) are an important mechanism for non-conventional secretion in both ascomycetes and basidiomycetes. Histoplasma capsulatum EVs contain diverse proteins associated with virulence and are immunologically active. Despite the growing knowledge of EVs from H. capsulatum and other pathogenic fungi, the extent that changes in the environment impact the sorting of organic molecules in EVs has not been investigated. In this study, we cultivated H. capsulatum with distinct culture media to investigate the potential plasticity in EV loading in response to differences in nutrition. Our findings reveal that nutrition plays an important role in EV loading and formation, which may translate into differences in biological activities of these fungi in various fluids and tissues. | en_US |
| Afiliación | Department of Medicine (Division of Infectious Diseases) and Department of Microbiology and Immunology. Albert Einstein College of Medicine. Bronx, USA. | |
| Afiliación | Department of Medicine (Division of Infectious Diseases) and Department of Microbiology and Immunology. Albert Einstein College of Medicine. Bronx, USA. | |
| Afiliación | Department of Medicine (Division of Infectious Diseases) and Department of Microbiology and Immunology. Albert Einstein College of Medicine. Bronx, USA / Biological Sciences Division, Pacific Northwest National Laboratory. Richland. USA / Bruker Daltonics Inc. Billerica, USA. | |
| Afiliación | Biological Sciences Division. Pacific Northwest National Laboratory. Richland, USA. | |
| Afiliación | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, Brazil. | |
| Afiliación | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, Brazil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil. | |
| Afiliación | Biological Sciences Division. Pacific Northwest National Laboratory. Richland, USA. | |
| Afiliación | Department of Medicine (Division of Infectious Diseases) and Department of Microbiology and Immunology. Albert Einstein College of Medicine. Bronx, USA. | |
| Afiliación | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brazil. | |
| Palavras clave en Inglês | BHI | en_US |
| Palavras clave en Inglês | Culture media | en_US |
| Palavras clave en Inglês | Dimorphic fungus | en_US |
| Palavras clave en Inglês | Extracellular vesicles | en_US |
| Palavras clave en Inglês | Ham's F12 | en_US |
| Palavras clave en Inglês | Histoplasma capsulatum | en_US |
| Palavras clave en Inglês | Histoplasmosis | en_US |
| Palavras clave en Inglês | Lipidomics | en_US |
| Palavras clave en Inglês | Metabolomics | en_US |
| Palavras clave en Inglês | Proteomics | en_US |
| Palavras clave en Inglês | RPMI | en_US |
| Palavras clave en Inglês | USA | en_US |
| Palavras clave en Inglês | Histoplasma-capsulatum | en_US |
| Palavras clave en Inglês | Lipids | en_US |
| e-ISSN | 1462-5822 |
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