| Author | Primo, Janeusa Rita Leite | |
| Author | Siqueira, Isadora Cristina de | |
| Author | Nascimento, M. C. F | |
| Author | Oliveira, M. F | |
| Author | Vale, Lourdes Farre | |
| Author | Carvalho Filho, Edgar Marcelino | |
| Author | Bittencourt, Achilea Candida Lisboa | |
| Access date | 2012-12-07T21:31:59Z | |
| Available date | 2012-12-07T21:31:59Z | |
| Document date | 2009 | |
| Citation | PRIMO, J. et al. High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. Brazilian Journal of Medical Biological Research, v. 42, n. 8, p. 761-764, aug. 2009. | pt_BR |
| ISSN | 0100-879X | |
| URI | https://www.arca.fiocruz.br/handle/icict/5941 | |
| Language | eng | pt_BR |
| Rights | open access | |
| Title | High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1 | pt_BR |
| Type | Article | pt_BR |
| Abstract | Salvador (BA, Brazil) is an endemic area for human T-cell lymphotrophic virus type 1 (HTLV-1). The overall prevalence of HTLV-1 infection in the general population has been estimated to be 1.76%. HTLV-1 carriers may develop a variety of diseases such as adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). IDH is a chronic and severe form of childhood exudative and infective dermatitis involving mainly the scalp, neck and ears. It has recently been observed that 30% of patients with IDH develop juvenile HAM/TSP. The replication of HTLV-1 has been reported to be greater in adult HAM/TSP patients than in asymptomatic HTLV-1 carriers. In the current study, the proviral load of 28 children and adolescents with IDH not associated with HAM/TSP was determined and the results were compared to those obtained in 28 HTLV-1 adult carriers and 28 adult patients with HAM/TSP. The proviral load in IDH patients was similar to that of patients with HAM/TSP and much higher than that found in HTLV-1 carriers. The high levels of proviral load in IDH patients were not associated with age, duration of illness, duration of breast-feeding, or activity status of the skin disease. Since proviral load is associated with neurological disability, these data support the view that IDH patients are at high risk of developing HAM/TSP. | pt_BR |
| Affilliation | Departamento de Medicina Interna. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Prof. Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Prof. Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Affilliation | Departamento de Medicina Interna. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Prof. Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Prof. Edgard Santos. Salvador, BA, Brasil | pt_BR |
| Subject | Infective dermatitis associated with HTLV-1 | pt_BR |
| Subject | HTLV-1-associated myelopathy/tropical spastic paraparesis | pt_BR |
| Subject | HTLV-1 proviral loads | pt_BR |
| DeCS | Dermatite/virologia | pt_BR |
| DeCS | Virus Linfotrópico de Células T Humanas | pt_BR |
| DeCS | Tipo 1/isolamento & purificação | pt_BR |
| DeCS | Paraparesia Espástica Tropical/virologia | pt_BR |
| DeCS | Dermatopatias Virais/virologia | pt_BR |
| DeCS | Marcadores Biológicos/análise | pt_BR |
| DeCS | Portador Sadio | pt_BR |
| DeCS | DNA Viral/análise | pt_BR |
| DeCS | Progressão da Doença | pt_BR |
| DeCS | Virus Linfotrópico de Células T Humanas | pt_BR |
| DeCS | Tipo 1/genética | pt_BR |
| DeCS | Provirus/genética | pt_BR |
| DeCS | Fatores de Risco | pt_BR |
| DeCS | Carga Viral | pt_BR |
| DeCS | Adolescente | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Criança | pt_BR |
| DeCS | Pré-Escolar | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Humanos | pt_BR |
