Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5941
Title: High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
Authors: Primo, Janeusa Rita Leite
Siqueira, Isadora Cristina de
Nascimento, M. C. F
Oliveira, M. F
Vale, Lourdes Farre
Carvalho Filho, Edgar Marcelino
Bittencourt, Achilea Candida Lisboa
Affilliation: Departamento de Medicina Interna. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospitalar Universitário Prof. Edgard Santos. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospitalar Universitário Prof. Edgard Santos. Salvador, BA, Brasil
Departamento de Medicina Interna. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospitalar Universitário Prof. Edgard Santos. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospitalar Universitário Prof. Edgard Santos. Salvador, BA, Brasil
Abstract: Salvador (BA, Brazil) is an endemic area for human T-cell lymphotrophic virus type 1 (HTLV-1). The overall prevalence of HTLV-1 infection in the general population has been estimated to be 1.76%. HTLV-1 carriers may develop a variety of diseases such as adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). IDH is a chronic and severe form of childhood exudative and infective dermatitis involving mainly the scalp, neck and ears. It has recently been observed that 30% of patients with IDH develop juvenile HAM/TSP. The replication of HTLV-1 has been reported to be greater in adult HAM/TSP patients than in asymptomatic HTLV-1 carriers. In the current study, the proviral load of 28 children and adolescents with IDH not associated with HAM/TSP was determined and the results were compared to those obtained in 28 HTLV-1 adult carriers and 28 adult patients with HAM/TSP. The proviral load in IDH patients was similar to that of patients with HAM/TSP and much higher than that found in HTLV-1 carriers. The high levels of proviral load in IDH patients were not associated with age, duration of illness, duration of breast-feeding, or activity status of the skin disease. Since proviral load is associated with neurological disability, these data support the view that IDH patients are at high risk of developing HAM/TSP.
Keywords: Infective dermatitis associated with HTLV-1
HTLV-1-associated myelopathy/tropical spastic paraparesis
HTLV-1 proviral loads
DeCS: Dermatite/virologia
Virus Linfotrópico de Células T Humanas
Tipo 1/isolamento & purificação
Paraparesia Espástica Tropical/virologia
Dermatopatias Virais/virologia
Marcadores Biológicos/análise
Portador Sadio
DNA Viral/análise
Progressão da Doença
Virus Linfotrópico de Células T Humanas
Tipo 1/genética
Provirus/genética
Fatores de Risco
Carga Viral
Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Masculino
Humanos
Issue Date: 2009
Citation: PRIMO, J. et al. High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. Brazilian Journal of Medical Biological Research, v. 42, n. 8, p. 761-764, aug. 2009.
ISSN: 0100-879X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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