Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5949
Title: Effect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection
Authors: Souza, R. M.
Freitas, Luiz Antonio Rodrigues de
Lyra, André de Castro
Moraes, C. F.
Braga, Eduardo Lorens
Lyra, Luiz Guilherme Costa
Affilliation: Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Salvador, Bahia, Brasil
Hospital São Rafael. Serviço de Gastro-Hepatologia. Salvador, Bahia, Btasil
Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Salvador, Bahia, Brasil
Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Salvador, Bahia, Brasil
Abstract: The objective of the present study was to determine the presence of hepatic iron overload in patients with chronic HCV infection and to correlate it with histologic alterations, HCV genotype and response to therapy. Liver tissue samples from 95 patients with chronic hepatitis C were divided into two groups: group I, presence of iron overload in hepatic tissue (Perls' staining) and group II, no iron overload. Hepatic iron overload was detected in 30 (31.6 percent) of 95 patients. Of the 69 patients tested by genotyping, 49 (71.01 percent) were genotype 1 and 20 (28.99 percent) genotype non-1. Iron overload was detected in 14 (28.6 percent) patients with genotype 1 and in 6 (30 percent) with genotype non-1 (P = 0.906). There was a significant difference in fibrosis stage between groups (P = 0.005). In group I (N = 30), one patient had stage F0/F1 of fibrosis, while in group II (N = 65), 22 (33.8 percent) patients had minimal or no fibrosis. Fibrosis stage F2/F3 was observed in 70 percent of group I patients compared to 46.2 percent of group II. Eighty-five patients were treated with a combination of interferon and ribavirin; 29 of them (34.1 percent) had a sustained virologic response and 8 (27.6 percent) of them had hepatic iron overload. Iron overload was detected in 18 (32.1 percent) of the 56 non-responders (P = 0.73). Hepatic iron overload was frequent among patients with chronic hepatitis C and was associated with a more severe stage of liver fibrosis. There was no association between iron overload and HCV genotype and response to interferon and ribavirin therapy.
Keywords: Hepatitis C infection
Iron overload
Genotype
Inflammatory activity
Fibrosis
Antiviral therapy
virina/uso terapêutico
Hepatite C Crônica/quimioterapia
DeCS: Hepatite C Crônica/complicações
Sobrecarga de Ferro/complicações
Interferon alfa/uso terapêutico
Antivirais/uso terapêutico
Hepatite C Crônica/patologia
Hepacivirus/genética
Hepacivirus/efeitos de drogas
Reação em Cadeia da Polimerase
Quimioterapia Combinada
Índice de Gravidade de Doença
Genótipo
Humanos
Masculino
Feminino
Adolescente
Adulto
Meia-Idade
Idoso
Issue Date: 2006
Citation: SOUZA, R. M. et al. Effect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection. Brazilian Journal of Medical Biological Researc = Revista Brasileira de Pesquisas Médicas e Biológicas, v. 39, n. 1, p. 79-83, jan. 2006.
ISSN: 0100-879X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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