Title:	Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis
Authors:	Costa, Alinne Silva Andrade Costa, Graciomar Conceição Aquino, Dorlene Maria Cardoso de Mendonça, Vitor Rosa Ramos de Barral, Aldina Maria Prado Barral Netto, Manoel Caldas, Arlene de Jesus Mendes
Affilliation:	Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil Universidade Federal do Maranhão. Departamento de PatologiaSaúde Pública. São Luís, MA, Brasil Universidade Federal do Maranhão. Departamento de Enfermagem. São Luís, MA, Brasil Universidade Federal do Maranhão. São Luís, MA, Brasil Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil Universidade Federal do Maranhão. Departamento de PatologiaSaúde Pública. São Luís, MA, Brasil
Abstract:	t is not well established whether cytokine production differs in response to different clinical forms of visceral leishmaniasis (VL). In this work, we performed a cross-sectional study to investigate the plasma levels of cytokines [interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-10 and IL-12] involved in the pathogenesis of VL in 80 subjects from VL endemic areas, including subjects with active VL, subjects with asymptomatic infection, subjects with cured VL and uninfected controls. The patients were recruited by sampling from a referral hospital and by random selection from a population-based cohort study. The results showed significant differences in the plasma concentration of all cytokines between the groups (p < 0.05). Patients with the active disease had higher plasma levels of IL-10, IL-4, INF-γ and TNF-α relative to the other groups and they produced more IL-12 than asymptomatic and cured subjects. Only the IL-2 concentration was higher in the asymptomatic and cured subjects relative to the patients with active disease (p < 0.05). Our results suggest that these cytokines can be used as markers in epidemiological studies conducted in endemic areas to distinguish between different clinical forms of VL. However, their usefulness should be confirmed in investigations conducted in other endemic areas.(
Keywords:	Cytokines Visceral leishmaniasis Clinical forms
Issue Date:	2012
Citation:	COSTA, A. S. A. et al. Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis. Memórias do Instituo Oswaldo Cruz, v. 107, n. 6, p. 735-739, sept. 2012.
ISSN:	0074-0276
Copyright:	open access
Appears in Collections:	BA - IGM - Artigos de Periódicos

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