Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5957
Title: Ticks, ivermectin, and experimental Chagas disease
Authors: Dias, João Carlos Pinto
Schofield, Christopher John
Machado, Evandro Marques de Menezes
Fernandes, Alexandre José
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Posto Avançado Emmanuel Dias. Bambui, MG, Brasil.
London School of Hygiene and Tropical Medicine. Pathogen Molecular Biology Unit, London, UK.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Posto Avançado Emmanuel Dias. Bambui, MG, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Posto Avançado Emmanuel Dias. Bambui, MG, Brasil.
Abstract: Following an infestation of dogticks in kennels housing dogs used for long-term studies of the pathogenesis of Chagas disease, we examined the effect of ivermectin treatment on the dogs, ticks, trypanosome parasites, and also on triatomine vectors of Chagas disease. Ivermectin treatment was highly effective in eliminating the ticks, but showed no apparent effect on the dogs nor on their trypanosome infection. Triatominae fed on the dogs soon after ivermectin treatment showed high mortality, but this effect quickly declined for bugs fed at successive intervals after treatment. In conclusion, although ivermectin treatment may have a transient effect on peridomestic populations of Triatominae, it is not the treatment of choice for this situation. The study also showed that although the dogticks could become infected with Trypanosoma cruzi, this only occurred when feeding on dogs in the acute phase of infection, and there was no evidence of subsequent parasite development in the ticks.
Keywords: Chagas disease
Trypanosoma cruzi
Rhipicephalus sanguineus
ivermectin
Triatominae
Issue Date: 2005
Citation: DIAS, João Carlos Pinto et al. Ticks, ivermectin, and experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 8, p. 829-832, Dec. 2005.
ISSN: 0037-8682
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos

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