Please use this identifier to cite or link to this item:
Type
ArticleCopyright
Open access
Sustainable Development Goals
03 Saúde e Bem-EstarCollections
Metadata
Show full item record
DETERMINANTES DA MORTALIDADE EM 10 ANOS DE IDOSOS BRASILEIROS RESIDENTES NA COMUNIDADE: ESTUDO DE COORTE DE IDOSOS DE BAMBUÍ.
Alternative title
SP3-12?Predictors of 10-year mortality in a community-dwelling population of Brazilian elderly: the BambuÍ cohort study of ageingAuthor
Affilliation
Abstract in Portuguese
Foram utilizadas informações de 1.399 participantes (> 60 anos) do Estudo de Coorte de Idosos de Bambuí, para examinar os determinantes da mortalidade em uma população com nível socioeconômico baixo. Entre 1997 e 2007, 599 participantes faleceram e 6,2% foram perdidos para acompanhamento, resultando em 12.415 pessoas-ano de observação. A taxa de mortalidade foi de 48,3 por mil pessoas-ano. Idade (hazard ratio ajustada [HR] = 1,40), sexo masculino (HR = 1,80), ser solteiro (HR = 1,78) ou viúvo (HR = 1,26), pior autoavaliação da saúde (HR = 1,31), incapacidade para realizar quatro ou mais atividades da vida diária (HR = 3,29), número de fatores de risco cardiovascular (HR = 1,51 para dois e HR = 1,91 para três ou mais), infecção pelo Trypanosoma cruzi (HR = 1,27) e número de medicamentos (HR = 1,06) apresentaram associações significantes (p < 0,05) e independentes com o evento. O escore do Mini-Exame do Estado Mental mostrou efeito protetor (HR = 0,96). Exceto a infecção pelo T. cruzi, os outros preditores da mortalidade foram consistentes com o observado em populações idosas com melhor situação socioeconômica.
Abstract
Background: The Trypanosoma cruzi genome was sequenced from a hybrid strain (CL Brener). However, high allelic variation and the repetitive nature of the genome have prevented the complete linear sequence of chromosomes being determined. Determining the full complement of chromosomes and establishing syntenic groups will be important in defining the structure of T. cruzi chromosomes. A large amount of information is now available for T. cruzi and Trypanosoma brucei, providing the opportunity to compare and describe the overall patterns of chromosomal evolution in these parasites. Methodology/Principal Findings: The genome sizes, repetitive DNA contents, and the numbers and sizes of chromosomes of nine strains of T. cruzi from four lineages (TcI, TcII, TcV and TcVI) were determined. The genome of the TcI group was statistically smaller than other lineages, with the exception of the TcI isolate Tc1161 (Jose-IMT). Satellite DNA content was correlated with genome size for all isolates, but this was not accompanied by simultaneous amplification of retrotransposons. Regardless of chromosomal polymorphism, large syntenic groups are conserved among T. cruzi lineages. Duplicated chromosome-sized regions were identified and could be retained as paralogous loci, increasing the dosage of several genes. By comparing T. cruzi and T. brucei chromosomes, homologous chromosomal regions in T. brucei were identified. Chromosomes Tb9 and Tb11 of T. brucei share regions of syntenic homology with three and six T. cruzi chromosomal bands, respectively. Conclusions: Despite genome size variation and karyotype polymorphism, T. cruzi lineages exhibit conservation of chromosome structure. Several syntenic groups are conserved among all isolates analyzed in this study. The syntenic regions are larger than expected if rearrangements occur randomly, suggesting that they are conserved owing to positive selection. Mapping of the syntenic regions on T. cruzi chromosomal bands provides evidence for the occurrence of fusion and split events involving T. brucei and T. cruzi chromosomes
Share