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EFFECTS OF AQUEOUS EXTRACT OF ECHINODORUS GRANDIFLORUS ON THE IMMUNE RESPONSE IN OVALBUMIN-INDUCED PULMONARY ALLERGY
Brugiolo, Alessa Sin Singer et al. | Date Issued: 2011
Author
Brugiolo, Alessa Sin Singer
Alves, Caio César de Souza
Gouveia, Ana Cláudia Carvalho
Dias, Alyria Teixeira
Rodrigues, Michele Fernandes
Pacífico, Lucila Grossi Gonçalves
Aarestrup, Beatriz Julião Vieira
Machado, Marco Antonio
Domingues, Robert
Teixeira, Henrique Couto
Gameiro, Jacy
Ferreira, Ana Paula
Affilliation
Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil
Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil
Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil
Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil
Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brazil
Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Morfologia. Juiz de Fora, MG, Brazil
Empresa Brasileira de Pesquisa Agropecuária. Centro Nacional de Pesquisa de Gado de Leite. Juiz de Fora, MG, Brazil
Empresa Brasileira de Pesquisa Agropecuária. Centro Nacional de Pesquisa de Gado de Leite. Juiz de Fora, MG, Brazil
Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil
Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil
Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil
Abstract
Background: Asthma is a disease characterized by intermittent obstruction of the airways and chronic inflammation that affects approximately 300 million people worldwide. The immune response in asthma is predominantly T(H)2, with high levels of total and allergen-specific IgE and bronchial eosinophilia. Asthma treatment is aimed at controlling the disease, and the drugs used currently have systemic adverse effects and generally are not effective in difficult-to-control cases. Objective: To investigate the effect of aqueous extract of Echinodorus grandiflorus, a plant used in folk medicine for its diuretic and anti-inflammatory properties, in a model of pulmonary allergy. Methods: BALB/c mice were intraperitoneally sensitized and nasally challenged with ovalbumin. Aqueous extract and dexamethasone treatments (0.1 mL/d per mouse) were initiated on day 32 and concluded on day 40. Eight hours after the last challenge evaluations, of serum, bronchoalveolar lavage, and lung tissue were performed. Results: Oral treatment with the extract markedly reduced the number of total cells and eosinophils in bronchoalveolar lavage. The eosinophil peroxidase activity in lung tissue, the levels of ovalbumin-specific IgE in serum, the levels of CCL 11, and the gene expression of interleukin 4 and interleukin 13 in lung tissue were also lower after treatment. Conclusions: These results suggest that the aqueous extract of E grandiflorus is able to modulate allergic pulmonary inflammation and may be useful as a potential therapeutic agent for asthma. Ann Allergy Asthma Immunol. 2011;106:481-488
Publisher
American College of Allergy, Asthma, and Immunology
Citation
BRUGIOLO, Alessa Sin Singer et al. Effects of aqueous extract of Echinodorus grandiflorus on the immune response in ovalbumin-induced pulmonary allergy. Ann Allergy Asthma Immunol., v. 106, n. 6, p. 481-488, 2011. doi: 10.1016/j.anai.2011.01.008.
DOI
10.1016/j.anai.2011.01.008
ISSN
1081-1206