| Author | Costa, Maria Fernanda Furtado Lima | |
| Author | Peixoto, Sérgio William Viana | |
| Author | Ribeiro, Antonio Luiz Pinho | |
| Access date | 2023-07-28T16:41:39Z | |
| Available date | 2023-07-28T16:41:39Z | |
| Document date | 2010 | |
| Citation | COSTA, Maria Fernanda Lima; PEIXOTO, Sérgio William Viana; RIBEIRO, Antonio Luiz Pinho. Chagas disease and mortality in old age as an emerging issue: 10 year follow-up of the Bambuí population-based cohort study (Brazil). Int J Cardiol., v. 145, n. 2, p. 362-363, 2010. doi: 10.1016/j.ijcard.2010.02.036. | en_US |
| ISSN | 0167-5273 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59827 | |
| Language | eng | en_US |
| Publisher | Elsevier/North-Holland Biomedical Press | en_US |
| Rights | restricted access | |
| Title | Chagas disease and mortality in old age as an emerging issue: 10 year follow-up of the Bambu population-based cohort study (Brazil) | en_US |
| Type | Article | |
| DOI | 10.1016/j.ijcard.2010.02.036 | |
| Abstract | Earlier studies of the natural history of Chagas disease (ChD), which is caused by the protozoan Trypanosoma cruzi , had suggested that the consequences of the disease in the elderly are negligible. The objective of this study was to estimate long-term mortality in ChD in old age using data from a large population-based cohort study. The study was conducted in Bambui City (~15,000 inhabitants), Brazil. Participants were 1479 residents aged 60 years and over (84.9% from total), who were followed from 1997 to 2007. During a mean follow-up of 8.72 years, 567 participants died, resulting in a total of 12,896 person-years observation. The baseline prevalence of T. cruzi infection was 38.1%. T. cruzi infection was a strong predictor of mortality among cohort members, and this association remained largely significant after adjustments for age, sex, and conventional cardiovascular risk factors (hazard ratio [HR] = 1.56; 95% CI 1.32–1.85). Increased risks for mortality associated with T. cruzi infection were consistently observed in those aged 60–69 (HR= 1.79; 95%CI 1.37–1.85), 70–79 (HR=1.35; 95% CI 1.04–1.76) and 80 years and over (HR= 1.59; 95% CI 1.09–2.33). Overall, population attributable risk for mortality due to T. cruzi infection was 13.2% (95% CI 9.8–16.4). Our results indicate that ChD is a relevant individual and population health issue in old age, supporting the need for measures to reduce the burden of ChD in this growing segment of the population. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Ouro Preto. Escola de Nutrição. Ouro Preto, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brazil | en_US |
| Subject | Chagas disease | en_US |
| Subject | Elderly | en_US |
| Subject | Mortality | en_US |
| Embargo date | 2099-12-31 | |
