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PREVALENCE OF ARBOVIRUS ANTIBODIES IN YOUNG HEALTHY ADULT POPULATION IN BRAZIL
Cross-reactivity
Hemagglutination inhibition assay
Military personnel
Public health
Seroprevalence
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil / Centro de Instrução de Guerra na Selva. Manaus, AM, Brazil.
Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brazil.
Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brazil.
Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brazil.
Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brazil.
Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brazil.
Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander von Humboldt. Lima, Perú.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil / Centro de Instrução de Guerra na Selva. Manaus, AM, Brazil.
Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brazil.
Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brazil.
Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brazil.
Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brazil.
Instituto Evandro Chagas. Seção de Arbovirologia e Febres Hemorrágicas. Ananindeua, PA, Brazil.
Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander von Humboldt. Lima, Perú.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil.
Abstract
Background: The emergence and re-emergence of infectious diseases are a cause for worldwide concern. The introduction of Zika and Chikungunya diseases in the Americas has exposed unforeseen medical and logistical challenges for public health systems. Moreover, the lack of preventive measures and vaccination against known and emerging mosquito-transmitted pathogens, and the occurrence of unanticipated clinical complications, has had an enormous social and economic impact on the affected populations. In this study, we aimed to measure the seroprevalence of endemic and emerging viral pathogens in military personnel stationed in Manaus, Amazonas state. Methods: We measured the seropositivity of antibodies against 19 endemic and emerging viruses in a healthy military personnel group using a hemagglutination inhibition assay (HIA). Results: Overall, DENV positivity was 60.4%, and 30.9% of the individuals reacted against ZIKV. Also, 46.6%, 54.7%, 51.3% and 48.7% individuals reacted against West Nile virus (WNV), Saint Louis encephalitis virus (SLEV), Ilheus virus (ILHV) and Rocio virus (ROCV), respectively. Individuals with high DENV HIA titer reacted more frequently with ZIKV or WNV compared to those with low HIA titers. Observed cross-reactivity between Flaviviruses varied depending on the virus serogroup. Additionally, 0.6% and 0.3% individuals were seropositive for Oropouche virus (OROV) and Catu virus (CATUV) from the family Peribunyaviridae, respectively. All samples were negative for Eastern Equine Encephalitis virus (EEEV), Western Equine Encephalomyelitis virus (WEEV), Mayaro virus (MAYV), Mucambo virus (MUCV) and CHIKV from the family Togaviridae. Conclusions: A high proportion of individuals in our high-risk population (~ 60%) lacked antibodies against major endemic and emerging viruses, which makes them susceptible for further infections. Military personnel serving in the Amazon region could serve as sentinels to strengthen global infectious disease surveillance, particularly in remote areas.
Keywords
ArbovirusCross-reactivity
Hemagglutination inhibition assay
Military personnel
Public health
Seroprevalence
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