Author | Rego, Filipe Ferreira de Almeida | |
Author | Moraes, Laise de | |
Author | Giovanetti, Marta | |
Author | Silva, José Adriano Góes | |
Author | Torres, Felipe Guimarães | |
Author | Silva, Marcio de Oliveira | |
Author | Silva, Maria da Purificação Pereira da | |
Author | Weyenbergh, Johan Van | |
Author | Santos, Luciane Amorim | |
Author | Khouri, Ricardo | |
Access date | 2023-08-11T18:59:38Z | |
Available date | 2023-08-11T18:59:38Z | |
Document date | 2023 | |
Citation | REGO, Filipe Ferreira de Almeida al. Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil. Viruses, v. 15, n. 8, p. 1650, 2023. doi.org/10.3390/v15081650. | en_US |
ISSN | 1999-4915 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/60051 | |
Language | eng | en_US |
Publisher | MPDI | en_US |
Rights | open access | en_US |
Title | Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil | en_US |
Type | Article | en_US |
Abstract | Background: The HIV subtype D is generally associated with a faster decline in CD4+ T cell counts, a higher viral load, and a faster progression to AIDS. However, it is still poorly characterized in Brazil. In this study, we used genomics and epidemiological data to investigate the transmission dynamics of HIV subtype D in the state of Bahia, Northeast Brazil. (2) Methods: To achieve this goal, we obtained four novel HIV-1 subtype D partial pol genome sequences using the Sanger method. To understand the emergence of this novel subtype in the state of Bahia, we used phylodynamic analysis on a dataset comprising 3704 pol genome sequences downloaded from the Los Alamos database. (3) Results: Our analysis revealed three branching patterns, indicating multiple introductions of the HIV-1 subtype D in Brazil from the late 1980s to the late 2000s and a single introduction event in the state of Bahia. Our data further suggest that these introductions most likely originated from European, Eastern African, Western African, and Southern African countries. (4) Conclusion: Understanding the distribution of HIV-1 viral strains and their temporal dynamics is crucial for monitoring the real-time evolution of circulating subtypes and recombinant forms, as well as for designing novel diagnostic and vaccination strategies. We advocate for a shift to active surveillance, to ensure adequate preparedness for future epidemics mediated by emerging viral strains. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil | en_US |
Affilliation | Fundação Oswaldo Cruz Instituto Gonçalo Moniz. Salvador, BA, Brazil/Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brazil | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Sciences and Technologies for Sustainable Development and One Health. University of Campus Bio-Medico. Italy, Rome | en_US |
Affilliation | Fundação Oswaldo Cruz Instituto Gonçalo Moniz. Salvador, BA, Brazil/Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brazil/Estado da Bahia. Secretaria Estadual de Saúde. Centro Estadual Especializado em Diagnóstico, Assistência e Pesquisa. Salvador, BA, Brazil | en_US |
Affilliation | Fundação Oswaldo Cruz Instituto Gonçalo Moniz. Salvador, BA, Brazil | en_US |
Affilliation | Estado da Bahia. Secretaria Estadual de Saúde. Centro Estadual. Salvador, BA, Brazil | en_US |
Affilliation | Estado da Bahia. Secretaria Estadual de Saúde. Centro Estadual. Salvador, BA, Brazil | en_US |
Affilliation | Rega Institute for Medical Research. Department of Immunology, Microbiology and Transplantation. KU Leuven. Leuven, Belgium | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil/ Fundação Oswaldo Cruz Instituto Gonçalo Moniz. Salvador, BA, Brazil/Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brazil | en_US |
Affilliation | Fundação Oswaldo Cruz Instituto Gonçalo Moniz. Salvador, BA, Brazil/Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brazil/Rega Institute for Medical Research. Department of Immunology, Microbiology and Transplantation. KU Leuven. Leuven, Belgium | en_US |
Subject | HIV-1 subtype D | en_US |
Subject | phylodynamics | en_US |
Subject | genomic surveillance | en_US |