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PHYTOCHEMICAL STUDY OF MAGONIA PUBESCENS A. ST.-HIL. AND CYTOTOXICITY OF BRANCHES AQUEOUS EXTRACT ON BREAST CANCER AND LEUKEMIA CELLS.
Moraes, Acácio Raphael Aguiar et al. | Date Issued: 2023
Author
Moraes, Acácio Raphael Aguiar
Siqueira Filho, Ezequias Pessoa
Kohlhoff, Markus
Evangelista, Fernanda Cristina Gontijo
Sabino, Adriano de Paula
Vieira Filho, Sidney Augusto
Alcântara, Antônio Flávio de Carvalho
Duarte, Lucienir Pains
Sousa, Grasiely Faria de
Affilliation
Universidade Federal de Minas Gerais. Instituto de Ciência Exatas. Departamento de Química. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brazil
Universidade Federal de Ouro Preto. Departamento de Química. Ouro Preto, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciência Exatas. Departamento de Química. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciência Exatas. Departamento de Química. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciência Exatas. Departamento de Química. Belo Horizonte, MG, Brazil
Abstract
Magonia pubescens is a natural species from the Brazilian cerrado biome. Its fruits and seeds are used in the treatment of seborrheic dermatitis, a common inflammatory skin disease. In this work, the known compounds lapachol, stigmasterol, maniladiol and scopoletin were isolated from hexane and dichloromethane extracts of M. pubescens branches. The aqueous extract of this material was fractioned through a liquid-liquid partition and the obtained fractions were analyzed by UHPLC-MS/MS. The results obtained were compared with data from three databases, leading to the putative identification of 51 compounds from different classes, including flavonoids, saponins and triterpenes. The cytotoxicity of aqueous fractions was assayed against breast cancer (MDA-MB-231) and leukemia (THP-1 and K562) cells. The best activity was observed for fraction AE3 against MDA-MB-231 cells (IC50 30.72 µg.mL−1)
Keywords
Magonia pubescensA. St.-Hil
cytotoxicity
breast cancer cells
leukemia cells
UHPLC-MS/MS
 
Publisher
Taylor and Francis Group Ltda
Citation
MORAES, Acácio Raphael Aguiar et al. Phytochemical study of Magonia pubescens A. St.-Hil. and cytotoxicity of branches aqueous extract on breast cancer and leukemia cells. Natural Product Research, p. 1-5, 2023. doi.org/10.1080/14786419.2023.2227988.
ISSN
1478-6419