| Author | Pinotti, Francesco | |
| Author | Giovanetti, Marta | |
| Author | Lima, Maricelia Maia de | |
| Author | Cerqueira, Erenilde Marques de | |
| Author | Alcantara, Luiz Carlos Júnior | |
| Author | Gupta, Sunetra | |
| Author | Recker, Mario | |
| Author | Lourenço, José | |
| Access date | 2023-08-31T14:08:52Z | |
| Available date | 2023-08-31T14:08:52Z | |
| Document date | 2023 | |
| Citation | FRANCESCO, Pinotti et al. Shifting patterns of dengue three years after Zika virus emergence in Brazil. medRxiv, p. 1-20, Jun. 2023. | |
| URI | https://www.arca.fiocruz.br/handle/icict/60281 | |
| Language | eng | en_US |
| Later version | https://www.arca.fiocruz.br/handle/icict/62689 | |
| Rights | restricted access | |
| Title | Shifting patterns of dengue three years after Zika virus emergence in Brazil | en_US |
| Type | Preprint | |
| DOI | 10.1101/2023.05.29.23290597 | |
| Abstract | The Zika virus (ZIKV) emerged in Brazil in 2015, causing large outbreaks across South America and the Caribbean. In the years that followed, many countries in these areas reported exceptionally low circulation of Dengue virus (DENV), which later resurged in 2018-2019. Several hypotheses have been proposed to explain low DENV transmission, yet no consensus has been reached so far. We show that while short-term cross-protection induced by ZIKV can explain the temporary disappearance of DENV, it also predicts, in contrast with observations, a rising mean age of DENV incidence in the post-ZIKV era. We further demonstrate that disease enhancement of DENV, especially in primary infections in ZIKV-positive hosts, is required to remedy these shortfalls. Our results suggest that both population-level immunity to DENV and ZIKV contributed positively to the reduction in mean age of DENV incidence. | en_US |
| Affilliation | Department of Biology. University of Oxford. Oxford, United Kingdom. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil / Department of Science and Technology for Humans and the Environment. University of Campus Bio-Medico di Roma. Roma, Italy. | |
| Affilliation | Fundação Oswaldo Cruz. Gonçalo Muniz Institute. Genetics and Computational Biology. Laboratory of Haematology. Salvador, BA, Brazil. | |
| Affilliation | Centre of PostGraduation in Collective Health. Department of Health. Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brazil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil. | |
| Affilliation | Department of Biology. University of Oxford. Oxford, United Kingdom. | |
| Affilliation | Centre for Ecology and Conservation. University of Exeter. Penryn, United Kingdom. | |
| Affilliation | Biosystems and Integrative Sciences Institute. Faculdade de Ciências da Universidade de Lisboa. Lisboa, Portugal. | |
| Subject | Zika virus (ZIKV) | en_US |
| Subject | Dengue virus (DENV) | en_US |
| Subject | Zika virus | en_US |
| Subject | Latin America | en_US |
| Embargo date | 2030-12-31 | |
