Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/6048
Title: Leishmania infection in humans, dogs and sandflies in a visceral leishmaniasis endemic area in Maranhão, Brazil
Authors: Felipe, Ilana Mirian Almeida
Aquino, Dorlene Maria Cardoso de
Kuppinger, Oliver
Santos, Max Diego Cruz
Rangel, Maurício Eduardo Salgado
Barbosa, David Soeiro
Barral, Aldina Maria Prado
Werneck, Guilherme Loureiro
Caldas, Arlene de Jesus Mendes
Affilliation: Universidade Federal do Maranhão. Maranhão, São Luis, Brasil
Universidade Federal do Maranhão. Maranhão, São Luis, Brasil
Universidade Federal do Maranhão. Maranhão, São Luis, Brasil
Universidade Federal do Maranhão. Maranhão, São Luis, Brasil
Universidade Federal do Maranhão. Maranhão, São Luis, Brasil
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Rio de Janeiro, RJ, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Rio de Janeiro, RJ, Bahia, Brasil
Universidade Federal do Maranhão. Maranhão, São Luis, Brasil
Abstract: Leishmania infection in humans, dogs and sandflies was examined in the endemic visceral leishmaniasis (VL) municipality of Raposa, state of Maranhão, Brazil. In this study, we examined Leishmania chagasi infection in the blood serum of both humans and Canis familiaris and the natural Leishmania sp. infection rate in the sandfly vector, Lutzomyia longipalpis. Enzyme-linked immunosorbent assay, indirect immunofluorescence reaction and polymerase chain reaction were performed to detect Leishmania infections in humans, dogs and sandflies, respectively. Overall, 186 out of 986 studied human beings were infected with L. chagasi parasites, representing an infection prevalence of 18.9%. An even higher infection rate was detected in dogs, where 66 (47.8%) out of 138 were infected. Among all Lu. longipalpis captured (n = 1,881), only 26.7% were females. The Leishmania infection frequency for the vector Lu. longipalpis was 1.56%. Remarkably, all infected sandflies were found in the peridomiciliary area. Furthermore, a high incidence of asymptomatic forms of VL in the human and canine populations was observed. The results of this study suggest autochthonous transmission of L. chagasi in this endemic area for visceral leishmaniasis because infection by Leishmania sp. was identified in all important elements of the transmission chain.
Keywords: Serum prevalence
Lutzomyia longipalpis
Visceral leishmaniasis
Maranhão
Brazil
DeCS: Doenças do Cão
Doenças Endêmicas
Insetos Vetores
Leishmaniose Visceral
Leishmaniose Visceral/veterinária
Psychodidae
Brasil
ELISA
Técnica Indireta de Fluorescência para Anticorpo
Leishmania
Leishmaniose Visceral
Reação em Cadeia da Polimerase
Estações do Ano
Animais
Cães
Feminino
Humanos
Masculino
Research Support, Non-U.S. Gov't
Issue Date: 2011
Citation: FELIPE, I. M. A. et al. Leishmania infection in humans, dogs and sandflies in a visceral leishmaniasis endemic area in Maranhão, Brazil. Memórias do Instituto Oswaldo Cruz, v. 106, n. 2, p. 207-211, mar. 2011.
ISSN: 0074-0276
Appears in Collections:IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Felipe, Ilana Mirian Almeida et al. Leishmania infection in humans....pdf514.24 kBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.