Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/617
Title: Trends in drug resistance mutations in antiretroviral-naïve intravenous drug users of Rio de Janeiro
Authors: Teixeira, Sylvia Lopes Maia
Bastos, Francisco Inácio Pinkusfeld Monteiro
Hacker, Mariana de Andrea Vilas-Boas
Guimarães, Monick Lindenmeyer
Morgado, Mariza Gonçalves
Affilliation: Department of Immunology Laboratory of AIDS and Molecular Immunology Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
Department of Health Information, Center for Information on Science and Technology, FIOCRUZ, Rio de Janeiro, Brazil
Department of Health Information, Center for Information on Science and Technology, FIOCRUZ, Rio de Janeiro, Brazil
Department of Immunology Laboratory of AIDS and Molecular Immunology Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
Department of Immunology Laboratory of AIDS and Molecular Immunology Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
Department of Immunology Laboratory of AIDS and Molecular Immunology Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
Abstract: DNA sequencing of a pol gene fragment from drug-naive injecting drug users samples obtained at two time points of the Brazilian AIDS epidemic(Pre-HAARTera: 1994 to early 1997, n = 27; post-HAARTera: 1999-2001, n = 38) was undertaken to assess HIV-1 antiretroviral drug resistance mutations and subtyping profiles. Genotypic analysis revealed the presence of PR primary L90M, D30N, M461, and V82A mutations in 7.9% of the post- HAARTgroup, and a high frequency of secondary mutations (84.2%). Nucleoside RT-associated mutations were observed in 13.2%. In the pre- HAARTgroup, a higher frequency of RT mutations was observed (22.2%) and no PR primary mutations were found, in agreement with the introduction of protease inhibitors (Pis) in therapy du ring the same period. The identification of7 .9% of drug-naive injecting drug users already bearing RT/PR primary resistance mutations in the post- HAARTera group constitutes a major concern in terms of dissemination of drug resistant viruses. The resistance mutations profile ofthe individuals may reflect the context of antiretroviral treatment in Brazil at the sample collection periods (1994- 1997 and 1999-2001). In spite of the differences observed in the drug resistance profiles, similar frequencies of subtype B (63.0 vs. 73.7%), F (22.2 vs. 10.5%), and recombinant B/F (14.8 vs. 15.8%) viruses were found, respectively, in the pre- and post-HAART groups.
keywords: HIV-1
injecting drug users
genetic diversity
Issue Date: 2006
Publisher: Wiley InterScience
Citation: TEIXEIRA, S. L. M. et al. Trends in drug resistance mutations in antiretroviral-naïve intravenous drug users of Rio de Janeiro. Journal of Medical Virology, New York, v. 78, p. 764-769, 2006.
ISSN: 0146-6615
1096-9071 online
Copyright: open access
Appears in Collections:ICICT - Artigos de Periódicos

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