Author | Souza, Claudio Lima | pt_BR |
Author | Barbosa, Cynara Gomes | pt_BR |
Author | Moura Neto, José Pereira de | pt_BR |
Author | Barreto, José Henrique Silva | pt_BR |
Author | Reis, Mitermayer Galvão dos | pt_BR |
Author | Gonçalves, Marilda de Souza | pt_BR |
Access date | 2013-01-14T17:36:55Z | |
Available date | 2013-01-14T17:36:55Z | |
Document date | 2008 | |
Citation | SOUZA, C. L. et al. Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients. Genetics and Molecular Biology, v. 31, n. 1, p. 39-41, 2008. | pt_BR |
ISSN | 1415-4757 | |
URI | https://www.arca.fiocruz.br/handle/icict/6179 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients | pt_BR |
Type | Article | pt_BR |
Abstract | The null genotype for glutathione S-transferase (GST, EC 2.5.1.18) gene polymorphisms is considered a risk factor for leukemia in different populations. In this work we investigated the GSTT1 and GSTM1 polymorphisms using multiplex PCR in 53 patients with chronic myeloid leukemia (CML), 23 with acute promyelocytic leukemia (APL) and 304 apparently healthy controls. In this association study we found that the GSTT1null genotype was more frequent in our group of APL patients than in the control group [OR = 2.75 (95 percent CI = 1.10-6.88)], providing evidence that a deletion in the GSTT1 gene could be a risk factor for this type of leukemia. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Clínica Onco. Salvador, Bahia, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil | pt_BR |
Subject | Acute promyelocytic leukemia | pt_BR |
Subject | Chronic myeloid leukemia | pt_BR |
Subject | GSTM1 | pt_BR |
Subject | GSTT1 | pt_BR |
Subject | Gene polymorphism | pt_BR |
DeCS | Glutationa Transferase | pt_BR |
DeCS | Leucemia Promielocítica Aguda | pt_BR |
DeCS | Leucemia Mielóide | pt_BR |
DeCS | Fatores de Risco | pt_BR |
DeCS | Polimorfismo Genético | pt_BR |
DeCS | Genótipo | pt_BR |
DeCS | Reação em Cadeia da Polimerase | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |