Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/6179
Title: Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
Authors: Souza, Claudio Lima
Barbosa, Cynara Gomes
Moura Neto, José Pereira de
Barreto, José Henrique Silva
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, Brasil
Universidade Federal da Bahia. Clínica Onco. Salvador, Bahia, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Abstract: The null genotype for glutathione S-transferase (GST, EC 2.5.1.18) gene polymorphisms is considered a risk factor for leukemia in different populations. In this work we investigated the GSTT1 and GSTM1 polymorphisms using multiplex PCR in 53 patients with chronic myeloid leukemia (CML), 23 with acute promyelocytic leukemia (APL) and 304 apparently healthy controls. In this association study we found that the GSTT1null genotype was more frequent in our group of APL patients than in the control group [OR = 2.75 (95 percent CI = 1.10-6.88)], providing evidence that a deletion in the GSTT1 gene could be a risk factor for this type of leukemia.
Keywords: Acute promyelocytic leukemia
Chronic myeloid leukemia
GSTM1
GSTT1
Gene polymorphism
DeCS: Glutationa Transferase
Leucemia Promielocítica Aguda
Leucemia Mielóide
Fatores de Risco
Polimorfismo Genético
Genótipo
Reação em Cadeia da Polimerase
Brasil
Humanos
Masculino
Feminino
Adolescente
Adulto
Issue Date: 2008
Citation: SOUZA, C. L. et al. Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients. Genetics and Molecular Biology, v. 31, n. 1, p. 39-41, 2008.
ISSN: 1415-4757
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Souza, Claudia Lima et al. Polymorphisms in the glutathione....pdf62.09 kBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.