| Author | Barbosa, Cynara Gomes | pt_BR |
| Author | Souza, Claudio Lima | pt_BR |
| Author | Moura Neto, José Pereira de | pt_BR |
| Author | Arruda, Maria da Gloria Bomfim | pt_BR |
| Author | Barreto, José Henrique Silva | pt_BR |
| Author | Reis, Mitermayer Galvão dos | pt_BR |
| Author | Gonçalves, Marilda de Souza | pt_BR |
| Access date | 2013-01-14T18:12:51Z | |
| Available date | 2013-01-14T18:12:51Z | |
| Document date | 2008 | |
| Citation | BARBOSA, C. G. et al. Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil. Genetics and Molecular Biology, v. 31, n. 1, p. 29-32, 2008. | pt_BR |
| ISSN | 1415-4757 | |
| URI | https://www.arca.fiocruz.br/handle/icict/6181 | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil | pt_BR |
| Type | Article | pt_BR |
| Abstract | Methylenetetrahydrofolate reductase (MTHFR: EC 1.5.1.20) polymorphisms are associated to acute lymphoid leukemia
in different populations. We used the polymerase chain reaction and the restriction fragment length polymorphism
method (PCR-RFLP) to investigateMTHFR C677T and A1298C polymorphism frequencies in 67 patients with
chronic myeloid leukemia (CML), 27 with acute myeloid leukemia FAB subtype M3 (AML-M3) and 100 apparently
healthy controls. The MTHFR mutant allele frequencies were as follows: CML = 17.2% for C677T, 21.6% for
A1298C; AML-M3 = 22.2% for C677T, 24.1% for A1298C; and controls = 20.5% for C677T, 21% for A1298C. Taken
together, our results provide evidence that MTHFR polymorphisms have no influence on the development of CML or
AML-M3 | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil | pt_BR |
| Affilliation | Faculdade de Medicina Edgard Santos. Hospital Universitário. Departamento de Hematologia. Salvador, Bahia, Brasil | pt_BR |
| Affilliation | Clinica Oncológica. Salvador, Bahia, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, Brasil | pt_BR |
| Subject | AML | pt_BR |
| Subject | CML | pt_BR |
| Subject | MTHFR polymorphisms | pt_BR |
| DeCS | Metilenotetraidrofolato Redutase (NADPH2) | pt_BR |
| DeCS | Leucemia Mielóide | pt_BR |
| DeCS | Frequência do Gene | pt_BR |
| DeCS | Leucemia Mielogênica Crônica BCR-ABL Positiva | pt_BR |
| DeCS | Polimorfismo de Fragmento de Restrição | pt_BR |
| DeCS | Reação em Cadeia da Polimerase | pt_BR |
| DeCS | Mutação | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Criança | pt_BR |
| DeCS | Adolescente | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Meia-Idade | pt_BR |
| DeCS | Idoso | pt_BR |
