Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/6181
Title: Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
Authors: Barbosa, Cynara Gomes
Souza, Claudio Lima
Moura Neto, José Pereira de
Arruda, Maria da Gloria Bomfim
Barreto, José Henrique Silva
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Faculdade de Medicina Edgard Santos. Hospital Universitário. Departamento de Hematologia. Salvador, Bahia, Brasil
Clinica Oncológica. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, Bahia, Brasil
Abstract: Methylenetetrahydrofolate reductase (MTHFR: EC 1.5.1.20) polymorphisms are associated to acute lymphoid leukemia in different populations. We used the polymerase chain reaction and the restriction fragment length polymorphism method (PCR-RFLP) to investigateMTHFR C677T and A1298C polymorphism frequencies in 67 patients with chronic myeloid leukemia (CML), 27 with acute myeloid leukemia FAB subtype M3 (AML-M3) and 100 apparently healthy controls. The MTHFR mutant allele frequencies were as follows: CML = 17.2% for C677T, 21.6% for A1298C; AML-M3 = 22.2% for C677T, 24.1% for A1298C; and controls = 20.5% for C677T, 21% for A1298C. Taken together, our results provide evidence that MTHFR polymorphisms have no influence on the development of CML or AML-M3
Keywords: AML
CML
MTHFR polymorphisms
DeCS: Metilenotetraidrofolato Redutase (NADPH2)
Leucemia Mielóide
Frequência do Gene
Leucemia Mielogênica Crônica BCR-ABL Positiva
Polimorfismo de Fragmento de Restrição
Reação em Cadeia da Polimerase
Mutação
Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Meia-Idade
Idoso
Issue Date: 2008
Citation: BARBOSA, C. G. et al. Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil. Genetics and Molecular Biology, v. 31, n. 1, p. 29-32, 2008.
ISSN: 1415-4757
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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