Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/6215
Title: Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
Authors: Santana, Nelma Pereira de
Freitas, Luiz Antonio Rodrigues de
Lyra, André de Castro
Paraná, Raymundo
Santana, Genoile
Trépo, Christian
Lyra, Luiz Guilherme Costa
Affilliation: Federal University of Bahia. Gastro-Hepatology Service Hospital Prof. Edgard Santos. / Hospital São Rafael. Gastro-hepatology Service. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Federal University of Bahia. Pathology Department. Salvador, Bahia, Brasil
Federal University of Bahia. Gastro-Hepatology Service Hospital Prof. Edgard Santos. / Hospital São Rafael. Gastro-hepatology Service. Salvador, Bahia, Brasil
University of Bahia. Post-graduate course in Medicine and Health Federal. Salvador, Bahia, Brasil
Federal University of Bahia. Gastro-Hepatology Service Hospital Prof. Edgard Santos. / Hospital São Rafael. Gastro-hepatology Service. Salvador, Bahia, Brasil
INSERM. Viral Hepatitis LAaoratory. Lyon, France
Federal University of Bahia. Gastro-Hepatology Service Hospital Prof. Edgard Santos. / Hospital São Rafael. Gastro-hepatology Service. Salvador, Bahia, Brasil
Abstract: Patients with chronic hepatitis C can have variable clinical progression. Hepatic histological alterations appear to be milder in asymptomatic subjects who have persistently normal ALT levels. Aims: To evaluate the severity of histological liver alterations in blood donors with normal and elevated ALT levels. Methods: We evaluated volunteer blood donors from the main blood bank of the city of Salvador-Brazil. Those who were anti-HCV positive were invited to participate in the study. Serum ALT and AST levels were measured at two time points, two months apart. Donors were divided into two groups: group I, individuals with ALT ≥ 1.5 times the upper limit of normal in at least one time point and group II, individuals with normal or near normal ALT, at both time points. Results: We evaluated 30,232 blood donors and 528 (1.7%) of them were anti-HCV positive. Eighty-two attended our service and HCV infection was confirmed in 66 individuals. Male gender predominated in both groups; the mean age was 36 for group I, and 33 for group II. Tattoos and intravenous illicit drug use were frequently-encountered risk factors. Liver biopsy was done in 43 subjects. Among donors with elevated ALT, two (10%) had minimum alterations, while in group II normal liver or minimum alterations were observed in six (26%) subjects. Chronic hepatitis or cirrhosis was encountered in 35 (81%) individuals: three (15%) and five (21%) subjects had chronic hepatitis without inflammatory activity, 10 (50%) and 11 (48%) had minimum to moderate activity and five (25%) and one (4.3%) had cirrhosis, in groups I and II, respectively (P was not significant). Conclusions: The prevalence of anti-HCV among this population of volunteer blood donors was 1.7%, and these subjects had few liver histological alterations or chronic hepatitis and cirrhosis. Liver injury severity was significant in patients with elevated ALT, however subjects with normal levels may also present chronic hepatitis and cirrhosis.
Keywords: ALT levels
Liver alterations
HCV
Northeast-Brazil
DeCS: Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Hepacivirus/imunologia
Hepatite C Crônica/patologia
Fígado/patologia
Doadores de Sangue
Brasil/epidemiologia
Ensaio de Imunoadsorção Enzimática
Anticorpos Anti-Hepatite C/sangue
Hepatite C Crônica/enzimologia
Hepatite C Crônica/epidemiologia
Fatores de Risco
Índice de Gravidade de Doença
Feminino
Humanos
Masculino
Issue Date: 2005
Citation: SANTANA, N. P. de et al. Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil. Brazilian Journal of Infectious Diseases, v. 9, n. 2, p. 134-141, apr. 2005.
ISSN: 1413-8670
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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