| Author | Brito-de-Sousa, Joaquim Pedro | |
| Author | Lima-Silva, Maria Luiza | |
| Author | Costa-Rocha, Ismael Artur da | |
| Author | Oliveira Júnior, Luiz Roberto Alves de | |
| Author | Azevedo, Ana Carolina Campi | |
| Author | Pascoal, Vanessa Peruhype Magalhães | |
| Author | Quetz, Josiane da Silva | |
| Author | Coelho-Dos-Reis, Jordana Grazziela Alves | |
| Author | Costa-Pereira, Christiane | |
| Author | Garcia, Cristiana Couto | |
| Author | Antonelli, Lis Ribeiro do Vale | |
| Author | Fonseca, Cristina Toscano | |
| Author | Lemos, Jandira Aparecida Campos | |
| Author | Mambrini, Juliana Vaz de Melo | |
| Author | Souza-Fagundes, Elaine Maria | |
| Author | Carvalho, Andréa Teixeira | |
| Author | Faria, Ana Maria de Caetano | |
| Author | Gomes, Angelica Oliveira | |
| Author | Torres, Karen Cecília de Lima | |
| Author | Martins Filho, Olindo Assis | |
| Access date | 2024-01-25T18:50:52Z | |
| Available date | 2024-01-25T18:50:52Z | |
| Document date | 2023 | |
| Citation | BRITO-DE-SOUSA, Joaquim Pedro et al. Rhythmic profile of memory T and B-cells along childhood and adolescence. Sci Rep., v. 13, n. 1, 20978, 2023. doi: 10.1038/s41598-023-48115-3. | en_US |
| ISSN | 2045-2322 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/62382 | |
| Language | eng | en_US |
| Publisher | Nature Publishing Group | en_US |
| Rights | restricted access | |
| Title | Rhythmic profile of memory T and B-cells along childhood and adolescence | en_US |
| Type | Article | |
| Abstract | Immunobiography describes the life-long effects of exogenous or endogenous stimuli on remodeling of immune cell biology, including the development of memory T and B-cells. The present study aimed at investigating the rhythms of changes in phenotypic features of memory T and B-cells along childhood and adolescence. A descriptive-observational investigation was conducted including 812 healthy volunteers, clustered into six consecutive age groups (9Mths-1Yr; 2Yrs; 3-4Yrs; 5-7Yrs; 8-10Yrs; 11-18Yrs). Immunophenotypic analysis of memory T-cell (CD4+ and CD8+) and B-cell subsets were performed by flow cytometry. The results pointed out that memory-related biomarkers of T and B-cells displayed a bimodal profile along healthy childhood and adolescence, regardless of sex. The first stage of changes occurs around 2Yrs, with predominance of naive cells, while the second and more prominent wave occurs around the age 8-10Yrs, with the prevalence of memory phenotypes. The neighborhood connectivity profile analysis demonstrated that the number of correlations reaches a peak at 11-18Yrs and lower values along the childhood. Males presented higher and conserved number of correlations when compared to females. Altogether, our results provide new insights into immunobiography and a better understanding of interactions among the cellular subsets studied here during childhood and adolescence. | en_US |
| Affilliation | Universidade Federal de Uberlândia. Programa de Pós-graduação em Imunologia e Parasitologia Aplicadas. Uberlândia, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Universidade Professor Edson Antônio Velano. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicadas. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Prefeitura de Belo Horizonte. Secretaria Municipal de Saúde. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicadas. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal do Triângulo Mineiro. Uberaba, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Professor Edson Antônio Velano. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Uberlândia. Programa de Pós-graduação em Imunologia e Parasitologia Aplicadas. Uberlândia, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Subject | Adolescent | en_US |
| Subject | B-Lymphocytes | en_US |
| Subject | CD4-Positive T-Lymphocytes | en_US |
| Subject | CD8-Positive T-Lymphocytes | en_US |
| Subject | Child | en_US |
| Subject | Female | en_US |
| Subject | Flow Cytometry | en_US |
| Subject | Humans | en_US |
| Subject | Immunologic Memory | en_US |
| Subject | Immunophenotyping | en_US |
| Subject | Male | en_US |
| Subject | T-Lymphocyte Subsets | en_US |
| Embargo date | 2030-12-31 | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
