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2030-12-31
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RHYTHMIC PROFILE OF MEMORY T AND B-CELLS ALONG CHILDHOOD AND ADOLESCENCE
Brito-de-Sousa, Joaquim Pedro et al. | Date Issued: 2023
Author
Brito-de-Sousa, Joaquim Pedro
Lima-Silva, Maria Luiza
Costa-Rocha, Ismael Artur da
Oliveira Júnior, Luiz Roberto Alves de
Azevedo, Ana Carolina Campi
Pascoal, Vanessa Peruhype Magalhães
Quetz, Josiane da Silva
Coelho-Dos-Reis, Jordana Grazziela Alves
Costa-Pereira, Christiane
Garcia, Cristiana Couto
Antonelli, Lis Ribeiro do Vale
Fonseca, Cristina Toscano
Lemos, Jandira Aparecida Campos
Mambrini, Juliana Vaz de Melo
Souza-Fagundes, Elaine Maria
Carvalho, Andréa Teixeira
Faria, Ana Maria de Caetano
Gomes, Angelica Oliveira
Torres, Karen Cecília de Lima
Martins Filho, Olindo Assis
Affilliation
Universidade Federal de Uberlândia. Programa de Pós-graduação em Imunologia e Parasitologia Aplicadas. Uberlândia, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Universidade Professor Edson Antônio Velano. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicadas. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Prefeitura de Belo Horizonte. Secretaria Municipal de Saúde. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicadas. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil.
Universidade Federal do Triângulo Mineiro. Uberaba, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Professor Edson Antônio Velano. Belo Horizonte, MG, Brazil.
Universidade Federal de Uberlândia. Programa de Pós-graduação em Imunologia e Parasitologia Aplicadas. Uberlândia, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Abstract
Immunobiography describes the life-long effects of exogenous or endogenous stimuli on remodeling of immune cell biology, including the development of memory T and B-cells. The present study aimed at investigating the rhythms of changes in phenotypic features of memory T and B-cells along childhood and adolescence. A descriptive-observational investigation was conducted including 812 healthy volunteers, clustered into six consecutive age groups (9Mths-1Yr; 2Yrs; 3-4Yrs; 5-7Yrs; 8-10Yrs; 11-18Yrs). Immunophenotypic analysis of memory T-cell (CD4+ and CD8+) and B-cell subsets were performed by flow cytometry. The results pointed out that memory-related biomarkers of T and B-cells displayed a bimodal profile along healthy childhood and adolescence, regardless of sex. The first stage of changes occurs around 2Yrs, with predominance of naive cells, while the second and more prominent wave occurs around the age 8-10Yrs, with the prevalence of memory phenotypes. The neighborhood connectivity profile analysis demonstrated that the number of correlations reaches a peak at 11-18Yrs and lower values along the childhood. Males presented higher and conserved number of correlations when compared to females. Altogether, our results provide new insights into immunobiography and a better understanding of interactions among the cellular subsets studied here during childhood and adolescence.
Keywords
Adolescent
B-Lymphocytes
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Child
Female
Flow Cytometry
Humans
Immunologic Memory
Immunophenotyping
Male
T-Lymphocyte Subsets
 
Publisher
Nature Publishing Group
Citation
BRITO-DE-SOUSA, Joaquim Pedro et al. Rhythmic profile of memory T and B-cells along childhood and adolescence. Sci Rep., v. 13, n. 1, 20978, 2023. doi: 10.1038/s41598-023-48115-3.
ISSN
2045-2322