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https://www.arca.fiocruz.br/handle/icict/62483
THE SOUND OF SILENT RNA IN TUBERCULOSIS AND THE INCRNA ROLE ON INFECTION
Author
Rocha, Eduardo Fukutani
Vinhaes, Caian Leal
Pereira, Mariana Araújo
Mota, Tiago Feitosa
Gupte, Akshay N.
Kumar, Nathella Pavan
Arriaga, Maria Belen
Sterling, Timothy R.
Babu, Subash
Gaikwad, Sanjay
Karyakarte, Rajesh
Mave, Vidya
Kulkarni, Vandana
Paradkar, Mandar
Viswanathan, Vijay
Kornfeld, Hardy
Gupta, Amita
Andrade, Bruno Bezerril
Queiroz, Artur Trancoso Lopo de
Vinhaes, Caian Leal
Pereira, Mariana Araújo
Mota, Tiago Feitosa
Gupte, Akshay N.
Kumar, Nathella Pavan
Arriaga, Maria Belen
Sterling, Timothy R.
Babu, Subash
Gaikwad, Sanjay
Karyakarte, Rajesh
Mave, Vidya
Kulkarni, Vandana
Paradkar, Mandar
Viswanathan, Vijay
Kornfeld, Hardy
Gupta, Amita
Andrade, Bruno Bezerril
Queiroz, Artur Trancoso Lopo de
Affilliation
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública (EBMSP). Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública (EBMSP). Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil.
Boston University School of Public Health. Boston, MA, USA.
ICMR-National Institute for Research in Tuberculosis. Chennai, India.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil.
Division of Infectious Diseases. Department of Medicine. Vanderbilt University Medical Center. Nashville, TN, USA.
National Institutes of Health. NIRT. International Center for Excellence in Research, Chennai, India.
Department of Pulmonary Medicine. Byramjee-Jeejeebhoy Government Medical College and Sassoon General Hospitals. Pune, India.
Department of Microbiology. Byramjee-Jeejeebhoy Government Medical College and Sassoon General Hospitals. Pune, India.
Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site. Pune, India / Johns Hopkins Center for Infectious Diseases in India. Pune, India.
Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site. Pune, India / Johns Hopkins Center for Infectious Diseases in India. Pune, India.
Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site. Pune, India / Johns Hopkins Center for Infectious Diseases in India. Pune, India.
Prof. M. Viswanathan Diabetes Research Centre. Chennai, India.
Department of Medicine. University of Massachusetts Medical School. Worcester, MA, USA / UMass Chan Medical School. Worcester, MA, USA.
Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site. Pune, India.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública (EBMSP). Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública (EBMSP). Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública (EBMSP). Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil.
Boston University School of Public Health. Boston, MA, USA.
ICMR-National Institute for Research in Tuberculosis. Chennai, India.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil.
Division of Infectious Diseases. Department of Medicine. Vanderbilt University Medical Center. Nashville, TN, USA.
National Institutes of Health. NIRT. International Center for Excellence in Research, Chennai, India.
Department of Pulmonary Medicine. Byramjee-Jeejeebhoy Government Medical College and Sassoon General Hospitals. Pune, India.
Department of Microbiology. Byramjee-Jeejeebhoy Government Medical College and Sassoon General Hospitals. Pune, India.
Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site. Pune, India / Johns Hopkins Center for Infectious Diseases in India. Pune, India.
Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site. Pune, India / Johns Hopkins Center for Infectious Diseases in India. Pune, India.
Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site. Pune, India / Johns Hopkins Center for Infectious Diseases in India. Pune, India.
Prof. M. Viswanathan Diabetes Research Centre. Chennai, India.
Department of Medicine. University of Massachusetts Medical School. Worcester, MA, USA / UMass Chan Medical School. Worcester, MA, USA.
Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site. Pune, India.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública (EBMSP). Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil.
Abstract
Tuberculosis (TB) is one of the leading causes of death worldwide, and Diabetes Mellitus is one of the major comorbidities (TB/DM) associated with the disease. A total of 103 differentially expressed ncRNAs have been identified in the TB and TB/DM comparisons. A machine learning algorithm was employed to identify the most informative lncRNAs: ADM-DT, LINC02009, LINC02471, SOX2-OT, and GK-AS1. These lncRNAs presented substantial accuracy in classifying TB from HC (AUCs >0.85) and TB/DM from HC (AUCs >0.90) in the other three countries. Genes with significant correlations with the five lncRNAs enriched common pathways in Brazil and India for both TB and TB/DM. This suggests that lncRNAs play an important role in the regulation of genes related to the TB immune response.
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