Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/6249
Title: Host nutritional status as a contributory factor to the remodeling of schistosomal hepatic fibrosis
Authors: Coutinho, Eridan de Medeiros
Barros, Andréia Ferreira de
Barbosa Junior, Aryon de Almeida
Oliveira, Sheilla Andrade de
Silva, Luciana Menezes da
Araújo, Roni Evencio de
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
Abstract: Weaning Swiss mice were percutaneously infected with 30 cercariae of Schistosoma mansoni and submitted to a shifting either from a deficient to a balanced diet or vice-versa, for 24 weeks. The nutritional status was weekly evaluated by measurements of growth curves and food intake. Hepatic fibrosis and periovular granulomas were studied by histological, morphometric and biochemical methods. All mice fed on a deficient diet failed to develop periportal "pipestem" fibrosis after chronic infection. An unexpected finding was the absence of pipestem fibrosis in mice on normal diet, probably related to the sample size. The lower values for nutritional parameters were mainly due to the deficient diet, rather than to infection. Liver/body weight ratio was higher in "early undernutrition" group, after shifting to the balanced diet. Volume density and numerical density of egg granulomas reached lowest values in undernourished animals. The amount of collagen was reduced in undernourished mice, attaining higher concentrations in well-fed controls and in "late undernutrition" (balanced diet shifted to a deficient one), where collagen deposition appeared increased in granulomas. That finding suggested interference with collagen degradation and resorption in "late" undernourished animals. Thus, host nutritional status plays a role in connective tissue changes of hepatic schistosomiasis in mice.
Keywords: Schistosoma mansoni
Undernutrition
Hepatic fibrosis
DeCS: Cirrose Hepática Experimental/parasitologia
Schistosoma mansoni
Cirrose Hepática Experimental/patologia
Tecido Conjuntivo/metabolismo
Tecido Conjuntivo/patologia
Granuloma/patologia
Granuloma/parasitologia
Contagem de Ovos de Parasitas
Tamanho do Órgão
Animais
Masculino
Camundongos
Issue Date: 2003
Citation: COUTINHO, E. M. et al. Host nutritional status as a contributory factor to the remodeling of schistosomal hepatic fibrosis. Memórias do Instituto Oswaldo Cruz, v. 98, n. 7, p. 919-925, Oct. 2003.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos
BA - IGM - Artigos de Periódicos

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