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TRANSMISSION-BLOCKING VACCINES FOR CANINE VISCERAL LEISHMANIASIS: NEW PROGRESS AND YET NEW CHALLENGES.
Author
Leite, Jaqueline Costa
Gonçalves, Ana Alice Maia
Oliveira, Diana Souza de
Resende, Lucilene Aparecida
Boas, Diego Fernandes Vilas
Ribeiro, Helen Silva
Pereira, Diogo Fonseca Soares
Silva, Augusto Ventura da
Mariano, Reysla Maria da Silveira
Reis, Pedro Campos Carvalhaes
Nakasone, Eiji
França-Silva, João Carlos
Galdino, Alexsandro Sobreira
Paes, Paulo Ricardo de Oliveira
Melo, Marília Martins
Dias, Edelberto Santos
Chávez-Fumagalli, Miguel Angel
Silveira-Lemos, Denise da
Dutra, Walderez Ornelas
Giunchetti, Rodolfo Cordeiro
Gonçalves, Ana Alice Maia
Oliveira, Diana Souza de
Resende, Lucilene Aparecida
Boas, Diego Fernandes Vilas
Ribeiro, Helen Silva
Pereira, Diogo Fonseca Soares
Silva, Augusto Ventura da
Mariano, Reysla Maria da Silveira
Reis, Pedro Campos Carvalhaes
Nakasone, Eiji
França-Silva, João Carlos
Galdino, Alexsandro Sobreira
Paes, Paulo Ricardo de Oliveira
Melo, Marília Martins
Dias, Edelberto Santos
Chávez-Fumagalli, Miguel Angel
Silveira-Lemos, Denise da
Dutra, Walderez Ornelas
Giunchetti, Rodolfo Cordeiro
Affilliation
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Microorganism Biotechnology Laboratory. Federal University of São João Del-Rei. Divinópolis, MG, Brazil.
Department of Veterinary Clinic and Surgery. School of Veterinary. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Department of Veterinary Clinic and Surgery. School of Veterinary. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Computational Biology and Chemistry Research Group. Vicerrectorado de Investigación. Universidad Católica de Santa María. Arequipa, Peru.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Microorganism Biotechnology Laboratory. Federal University of São João Del-Rei. Divinópolis, MG, Brazil.
Department of Veterinary Clinic and Surgery. School of Veterinary. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Department of Veterinary Clinic and Surgery. School of Veterinary. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Computational Biology and Chemistry Research Group. Vicerrectorado de Investigación. Universidad Católica de Santa María. Arequipa, Peru.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Laboratory of Biology of Cell Interactions. Department of Morphology. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.
Abstract
Dogs with visceral leishmaniasis play a key role in the transmission cycle of Leishmania infantum to humans in the urban environment. There is a consensus regarding the importance of developing a vaccine to control this disease. Despite many efforts to develop a protective vaccine against CVL, the ones currently available, Leish-tec® and LetiFend®, have limited effectiveness. This is due, in part, to the complexity of the immune response of the naturally infected dogs against the parasite and the complexity of the parasite transmission cycle. Thus, strategies, such as the development of a transmission-blocking vaccines (TBVs) already being applied to other vector-borne diseases like malaria and dengue, would be an attractive alternative to control leishmaniasis. TBVs induce the production of antibodies in the vertebrate host, which can inhibit parasite development in the vector and/or interfere with aspects of vector biology, leading to an interruption of parasite transmission. To date, there are few TBV studies for CVL and other leishmaniasis forms. However, the few studies that exist show promising results, thus justifying the further development of this approach.
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