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N-(COUMARIN-3-YL)CINNAMAMIDE PROMOTES IMMUNOMODULATORY, NEUROPROTECTIVE, AND LUNG FUNCTION-PRESERVING EFFECTS DURING SEVERE MALARIA
Gaio, Paulo et al. | Date Issued: 2024
Author
Gaio, Paulo
Cramer, Allysson
Oliveira, Natália Fernanda de Melo
Porto, Samuel
Kramer, Lucas
Rabelo, Rayane Aparecida Nonato
Pereira, Rafaela das Dores
Santos, Laura Lis de Oliveira
Barbosa, César Luís Nascimento
Oliveira, Fabrício Marcus Silva
Teixeira, Mauro Martins
Russo, Remo Castro
Matos, Maria João
Machado, Fabiana Simão
Affilliation
Federal University of Minas Gerais. Department of Biochemistry and Immunology. Institute of Biological Science. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. Department of Biochemistry and Immunology. Institute of Biological Science. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. Department of Biochemistry and Immunology. Institute of Biological Science. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. Department of Biochemistry and Immunology. Institute of Biological Science. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. Department of Biochemistry and Immunology. Institute of Biological Science. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. Department of Biochemistry and Immunology. Institute of Biological Science. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. Department of Biochemistry and Immunology. Institute of Biological Science. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. Department of Biochemistry and Immunology. Institute of Biological Science. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. Faculty of Medicine. Program in Health Sciences. Infectious Diseases and Tropical Medicine/Interdisciplinary Laboratory of Medical Investigation. Belo Horizonte, MG, Brazil.
Oswaldo Cruz Foundation. René Rachou Institute. Cellular and Molecular Immunology Group. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. Department of Biochemistry and Immunology. Institute of Biological Science. Belo Horizonte, MG, Brazil / Federal University of Minas Gerais. Faculty of Medicine. Program in Health Sciences. Infectious Diseases and Tropical Medicine/Interdisciplinary Laboratory of Medical Investigation. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. Institute of Biological Sciences. Department of Physiology and Biophysics. Laboratory of Pulmonary Immunology and Mechanics. Belo Horizonte, MG, Brazil.
Universidade de Santiago de Compostela. Facultad de Farmacia. Departamento de Química Orgánica. Santiago de Compostela, Spain.
Federal University of Minas Gerais. Institute of Biological Science. Department of Biochemistry and Immunology. Belo Horizonte, MG, Brazil / Federal University of Minas Gerais. Faculty of Medicine. Program in Health Sciences. Infectious Diseases and Tropical Medicine/Interdisciplinary Laboratory of Medical Investigation. Belo Horizonte, MG, Brazil.
Abstract
Plasmodium berghei ANKA (PbA) infection in mice resembles several aspects of severe malaria in humans, such as cerebral malaria and acute respiratory distress syndrome. Herein, the effects of N-(coumarin-3-yl)cinnamamide (M220) against severe experimental malaria have been investigated. Treatment with M220 proved to protect cognitive abilities and lung function in PbA-infected mice, observed by an object recognition test and spirometry, respectively. In addition, treated mice demonstrated decreased levels of brain and lung inflammation. The production and accumulation of microglia, and immune cells that produce the inflammatory cytokines TNF and IFN-γ, decreased, while the production of the anti-inflammatory cytokine IL-10 by innate and adaptive immune cells was enhanced. Treatment with M220 promotes immunomodulatory, neuroprotective, and lung function-preserving effects during experimental severe malaria. Therefore, it may be an interesting therapeutic candidate to treat severe malaria effects.
Keywords
N-(coumarin-3-yl)cinnamamide
Plasmodium berghei ANKA
Acute respiratory distress syndrome
Cerebral malaria
Immunoregulation
 
Publisher
MDPI
Citation
GAIO, Paulo et al. N-(coumarin-3-yl)cinnamamide Promotes Immunomodulatory, Neuroprotective, and Lung Function-Preserving Effects during Severe Malaria. Pharmaceuticals, v. 17, n. 1, p. 1-19, Jan. 2024.
DOI
10.3390/ph17010046
ISSN
1424-8247