Influence of dietary pattern on anti-tuberculosis treatment outcomes in persons with dysglycemia: a Peruvian prospective cohort study

Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine. Nashville, Tennessee, United States.
Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Centro Universitário Faculdade de Tecnologia e Ciências. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil.
Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil.
Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Fundação Oswaldo Cruz Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde (CIDACS). Salvador, BA, Brasil.
Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Salvador (UNIFACS). Curso de Medicina. Salvador, BA, Brasil.
Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Salvador (UNIFACS). Curso de Medicina. Salvador, BA, Brasil.
Universidade Virtual do Estado de São Paulo. Cidade Universitária. Butantã, São Paulo, SP, Brasil.
Department of Epidemiology. Columbia University Mailman School of Public Health. New York, United States.
Socios En Salud Sucursal Peru (Partners in Health). Lima, Peru / Department of Global Health and Social Medicine. Harvard Medical School. Boston, United States.
Socios En Salud Sucursal Peru (Partners in Health). Lima, Peru / Grupo de Investigación en Bioquímica y Biología Sintética. Universidad Nacional Federico Villarreal. Lima, Peru.
Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Centro Universitário Faculdade de Tecnologia e Ciências. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Universidade Salvador (UNIFACS). Curso de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação Baiana para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.

Abstract

Introduction: Dietary patterns (DPs) are associated with overall nutritional status and may alter the clinical prognosis of tuberculosis. This interaction can be further intricated by dysglycemia (i.e., diabetes or prediabetes). Here, we identified DPs that are more common with tuberculosis–dysglycemia and depicted their association with tuberculosis treatment outcomes. Methods: A prospective cohort study of persons with tuberculosis and their contacts was conducted in Peru. A food frequency questionnaire and a multidimensional systems biology-based analytical approach were employed to identify DPs associated with these clinical groups. Potential independent associations between clinical features and DPs were analyzed. Results: Three major DPs were identified. TB–dysglycemia cases more often had a high intake of carbohydrates (DP1). Furthermore, DP1 was found to be associated with an increased risk of unfavorable TB outcomes independent of other factors, including dysglycemia. Conclusion: Our findings suggest that the evaluation of nutritional status through DPs in comorbidities such as dysglycemia is a fundamental action to predict TB treatment outcomes. The mechanisms underlying the association between high intake of carbohydrates, dysglycemia, and unfavorable tuberculosis treatment outcomes warrant further investigation.

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Frontiers Media

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ARRIAGA, María B. et al. Influence of dietary pattern on anti-tuberculosis treatment outcomes in persons with dysglycemia: a Peruvian prospective cohort study. Frontiers in Nutrition, v. 10, p. 1-11, 2023.

DOI

10.3389/fnut.2023.1254983

ISSN

2296-861X

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/62784

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