Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/6291
Title: In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe
Authors: Bessa, Theolis Costa Barbosa
Arruda, Sérgio Marcos
Cavada, Benildo Sousa
Grangeiro, Thalles Barbosa
Freitas, Luiz Antonio Rodrigues de
Barral Netto, Manoel
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal do Ceará. Centro de Ciências. Fortaleza, CE, Brasil
Universidade Federal do Ceará. Centro de Ciências. Fortaleza, CE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: This paper reports the overall effects of three lectins, extracted from Canavalia brasiliensis, Dioclea violacea, and D. grandiflora, on BALB/c mice popliteal draining lymph nodes. These lectins have presented high stimulatory capacity on lymph node T cells. Additionally, they were able to induce apoptosis and inflammation (frequently associated with high endothelial venule necrosis). The data presented here suggest that the Diocleinae lectins studied can stimulate in vivo T cell activation and apoptosis, as well as present important side effects.
Keywords: Adjuvants
Apoptosis
Diocleinae
Lectin
Linfonodos/patologia
Sequência de Aminoácidos
DeCS: Ativação Linfocitária/efeitos de drogas
Apoptose/efeitos de drogas
Lectinas/farmacologia
Fabaceae/química
Linfonodos/efeitos de drogas
Fabaceae/genética
Inflamação/induzido quimicamente
Receptores de Interleucina-2/metabolismo
Vênulas/patologia
Endotélio/irrigação sanguínea
Necrose
Contagem de Células
Camundongos Endogâmicos BALB C
Animais
Camundongos
Masculino
Feminino
Research Support, Non-U.S. Gov't
Issue Date: 2001
Citation: BARBOSA, T. et al. In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe. Memórias do Instituto Oswaldo Cruz, v. 96, n. 5, p. 673-678, july. 2001.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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