Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/6304
Title: Immunological System and Schistosoma mansoni: Co-evolutionary Immunobiology. What is the Eosinophil Role in Parasite-host Relationship?
Authors: Lenzi, Henrique Leonel
Pacheco, Ronaldo G.
Machado, Marcelo Pelajo
Panasco, Monica de Souza
Romanha, Waldemiro de Souza
Lenzi, Jane A.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée Guinle. Departamento de Medicina Geral. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Abstract: Schistosomes, ancestors and recent species, have pervaded many hosts and several phylogenetic levels of immunity, causing an evolutionary pressure to eosinophil lineage expression and response. Schistosoma mansoni adult worms have capitalized on the apparent adversity of living within the mesenteric veins, using the dispersion of eggs and antigens to other tissues besides intestines to set a systemic activation of several haematopoietic lineages, specially eosinophils and monocytes/macrophages. This activation occurs in bone marrow, spleen, liver, lymph nodes, omental and mesenteric milky spots (activation of the old or primordial and recent or new lymphomyeloid tissue), increasing and making easy the migration of eosinophils, monocytes and other cells to the intestinal periovular granulomas. The exudative perigranulomatous stage of the periovular reaction, which present hystolitic characteristics, is then exploited by the parasites, to release the eggs into the intestinal lumen. The authors hypothesize here that eosinophils, which have a long phylogenic story, could participate in the parasite - host co-evolution, specially with S. mansoni, operating together with monocytes/ macrophages, upon parasite transmission.
Keywords: eosinophils
phylogeny
Schistosoma mansoni
granuloma
co-evolution
egg release
DeCS: Eosinófilos
Filogenia
Schistosoma mansoni
Granuloma
Sistema Imunológico
Issue Date: 1997
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: LENZI, H. L. et al. Immunological system and Schistosoma mansoni: co-evolutionary immunobiology. What is the eosinophil role in parasitic-host relationship?. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Sup. II, p. 19-32, 1997.
Description: Ackonowledgements to Luzia Fatima Gonçalves Caputo and Adelaide Lopes de Amorim for their expert technical assistance.
DOI: http://dx.doi.org/10.1590/S0074-02761997000800005
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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