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https://www.arca.fiocruz.br/handle/icict/64095
GENETIC VARIABILITY AMONG YELLOW FEVER VIRUS 17D SUBSTRAINS
Affilliation
Fundação Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de tecnologia em imunobiológicos (Bio-Manguinhos). Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
undação Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de tecnologia em imunobiológicos (Bio-Manguinhos). Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
undação Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de tecnologia em imunobiológicos (Bio-Manguinhos). Rio de Janeiro, RJ, Brasil.
Abstract in Portuguese
The complete nucleotide sequence of the genome from two yellow fever (YF) virus
strains, 1700 and 170-213 was determined. Comparison of these sequences with
those of other YF viruses, including the parental virulent Asihi strain, allowed the
identification of 48 nucleotide sequence differences which are I70 strain-specific and
potentially related to viral attenuation. Another 43 nucleotide sequence differences were
not common to all 170 substrains and are therefore substrain specific. Of the 21
changes between 1700 and Asibi 1.5 only five led to amino acid substitutions whereas
13 substrain differences common to all 170-204 substrains produced six amino acid
substitutions. Since the exact passage histories of these viruses is known it was possible
to calculate, for each strain, the number of accumulated changes per passage. Based
on these data the 1700 strain was the most genetically stable virus. 0 I998 Elsevier
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