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3100-12-31
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FOLLOW-UP OF COGNITIVE IMPAIRMENT AND INFLAMMATORY PROFILE IN INDIVIDUALS WITH MILD COVID-19.
Souza-Silva, Nathália Gualberto et al. | Date Issued: 2024
Author
Souza-Silva, Nathália Gualberto
Rosa, Daniela Valadão
Paula, Jonas Jardim de
Coimbra, Roney Santos
Miranda, Débora Marques
Romano-Silva, Marco Aurélio
Affilliation
Universidade Federal de Minas Gerais. Centro de Tecnologia em Medicina Molecular. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Centro de Tecnologia em Medicina Molecular. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Centro de Tecnologia em Medicina Molecular. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Psiquiatria. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou Neurogenômica/Imunopatologia. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Centro de Tecnologia em Medicina Molecular. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Pediatria. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Centro de Tecnologia em Medicina Molecular. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Psiquiatria. Belo Horizonte, MG, Brazil.
Abstract
Individuals who experience mild COVID-19 can suffer from long-lasting cognitive symptoms. Notably, 26% of these individuals experience difficulties with visuospatial abilities six months after infection. However, among those who initially exhibited visuoconstructive impairments, 66% showed improvement or complete reversal over time. Additionally, changes in cytokine levels, particularly CCL11, HGF, and CXCL10, were observed. These results suggest a potential link between ongoing cognitive issues and elevated levels of pro-inflammatory cytokines, which merits further investigation.
Keywords
Post-acute COVID-19 syndrome
Neuroinflammation
Cytokine
Cognitive symptoms
Visuospatial processing
 
Publisher
Elsevier/North-Holland
Citation
SOUZA-SILVA, Nathália Gualberto et al. Follow-up of cognitive impairment and inflammatory profile in individuals with mild COVID-19. J Neuroimmunol., v. 389, 578327, 2024. doi: 10.1016/j.jneuroim.2024.578327.
ISSN
0165-5728